昆明醫(yī)科大學(xué)類器官研究院院長

復(fù)旦大學(xué)生命科學(xué)學(xué)院,、附屬中山醫(yī)院雙聘教授

遺傳工程國家重點實驗室“類器官研究中心”主任PI

國家“優(yōu)秀青年基金”獲得者

國家重點研發(fā)計劃“干細(xì)胞及轉(zhuǎn)化研究”項目負(fù)責(zé)人（青年）

“東方學(xué)者”特聘教授,、上海市青年拔尖人才

通訊地址：上海市復(fù)旦大學(xué)生命科學(xué)學(xué)院A501室    郵編：200438

電話：18612372986    電子郵箱：[email protected]

教育,、工作經(jīng)歷

研究員	復(fù)旦大學(xué)	2017.4---至今
博士后	辛辛那提兒童醫(yī)學(xué)院醫(yī)學(xué)中心	2015.11---2017.3
博士后	清華-北大生命科學(xué)聯(lián)合中心	2013.7---2015.9
生物學(xué)博士	清華大學(xué)	2008.9---2013.6
理學(xué)學(xué)士	中國農(nóng)業(yè)大學(xué)	2005.9---2008.6

科研方向與主要成績

利用小鼠遺傳、類器官模型,，研究成體干細(xì)胞命運決定機(jī)制,，并發(fā)展類器官培育新策略。以第一/通訊作者身份于國際權(quán)威期刊Cell Research,、Nature Communications、 Advanced Science,、Protein & Cell,、Developmental Cell等發(fā)表系列性研究論文，為再生生物學(xué)發(fā)展提供重要基礎(chǔ),。代表性研究成果獲Nature News專訪報道,、Nature官網(wǎng)主頁高亮,，獲國際權(quán)威綜述期刊Nature Reviews Molecular Cell Biology、Nature Reviews Gastroenterology & Hepatology等高度評價,。

致力于推進(jìn)類器官技術(shù)標(biāo)準(zhǔn)化,，開拓醫(yī)藥應(yīng)用新場景。2018年創(chuàng)立復(fù)旦大學(xué)類器官中心,；主編或參編“十四五”國家重點研發(fā),、國家博士后創(chuàng)新創(chuàng)業(yè)、上海市重點,、廣東 省重點等多個類器官重點專項項目指南,；牽頭制定類器官培養(yǎng)行業(yè)標(biāo)準(zhǔn)規(guī)范；主筆類器官臨床應(yīng)用中國專家共識,；主辦年度類器官高峰論壇,；促進(jìn)藥審藥評鼓勵意見出臺。多維度打造類器官產(chǎn)業(yè)轉(zhuǎn)化和醫(yī)藥應(yīng)用行業(yè)新生態(tài),。

主持在研項目

獎勵與榮譽

復(fù)星醫(yī)藥獎教金（一等）	復(fù)旦大學(xué)	2020   2021
“東方學(xué)者”特聘教授	上海市教委	2019
上海市青年拔尖人才	上海市委組織部,，人社局	2018
上海市青年科技啟明星（A類）	上海市教委	2018
生命科學(xué)院院長獎	復(fù)旦大學(xué)	2018
AMGEN Postdoctoral Award	AMGEN	2015
北京市優(yōu)博	北京市教委	2013

其它工作

第八屆國務(wù)院學(xué)位辦生物學(xué)、生物工程學(xué)科評議組副秘書長

中國細(xì)胞生物學(xué)學(xué)會細(xì)胞治療研究與應(yīng)用分會委員

中國生物醫(yī)學(xué)工程學(xué)會類器官與器官芯片分會委員

中國微生物學(xué)會第十二屆理事會委員（細(xì)胞因子與干擾素專業(yè)委員會）

《Cell Transplantation》,、《遺傳》雜志編委

《Cell Regeneration》干細(xì)胞信號調(diào)控?？妥骶?/span>

《Organs-on-a-Chip》類器官專刊客座主編

復(fù)旦大學(xué)生物學(xué)博士后流動站專家委員

代表性學(xué)術(shù)論文

 1. Liu G, Wei J, Li X, Tian M, Wang Z, Shen C, Sun W, Li C, Li X, Lv E, Tian S, Wang J*, Xu S* and Zhao B*. (2022) Near-infrared-responded high sensitivity nanoprobe for steady and visualized detection of albumin in hepatic organoids and mouse liver. Advanced Science (工程技術(shù)1區(qū)Top), 9:2202505. (*corresponding author)

 2. Liang J, Qian J, Yang L, Chen X, Wang X, Lin X*, Wang X* and Zhao B*. (2022) Modeling human thyroid development by fetal tissue-derived organoid culture. Advanced Science (工程技術(shù)1區(qū)Top), 9:2105568.

 3. Ren X, Liang J, Zhang Y, Jiang N, Xu Y, Qiu M, Wang Y, Zhao B* and Chen X*. (2022) Single-cell transcriptomic atlas highlights origin and pathological process of human endometrioid endometrial carcinoma. Nature Communications (綜合1區(qū)Top), 13:6300.

 4. Sun S, Jiang Y, Zhang Q, Pan H, Li X, Yang L, Huang M, Wei W, Wang X, Qiu M, Cao L, He H, Yu M, Liu H, Zhao B*, Jiang N*, Li R* and Lin X*. (2022) Znhit1 controls meiotic initiation in male germ cells by coordinating with Stra8 to activate meiotic gene expression. Developmental Cell (生物1區(qū)Top), 57:901–913. (Cover Story)

 5. Wei W, Tang X, Jiang N, Ni C, He H, Sun S, Yu M, Yu C, Qiu M, Yan D, Zhou Z, Song Y, Liu H*, Zhao B* and Lin X*. (2022) Chromatin remodeler Znhit1 controls bone morphogenetic protein signaling in embryonic lung tissue branching. Journal of Biological Chemistry, 298:102490.

 6. Meng F, Shen C, Yang L, Ni C, Huang J, Lin K, Cao Z, Xu S, Cui W, Wang X, Zhou B, Xiong C, Wang J and Zhao B*. (2022) Mechanical stretching boosts expansion and regeneration of intestinal organoids through fueling stem cell self-renewal. Cell Regeneration, 11:39.

 7. Chen J, Zhang J, Yang L and Zhao B*. (2022) Facile suspension culture protocol of the liver biliary organoids. Bio-Design Engineering and Manufacture, doi.org/10.1007/s42242-022-00213-3.

 8. Yang L, Chen J, Liang J, Zhang Y, Wang Q, Ren X, Wei J, Gong Q, Zhang J, Jiang N, Lin X, Li J* and Zhao B*. (2022) Modeling hepatoblastoma development with human fetal liver organoids reveals YAP1 activation is sufficient for tumorigenesis. Protein & Cell (生物1區(qū)Top), 13:683-688.

 9. Huang M, Yang L, Jiang N, Dai Q, Li R, Zhou Z, Zhao B* and Lin X*. (2021) Emc3 maintains intestinal homeostasis by preserving secretory lineages. Mucosal Immunology (醫(yī)學(xué)1區(qū)Top), 14:873-886. (Cover Story and 2021 Editor’s Choice)

 10. Xiao H, Liang J, Liu S, Zhang Q, Xie F, Kong X, Guo S, Wang R, Fu R, Ye Z, Li Y, Zhang S, Zhang L, Kaudimba K, Wang R, Kong X, Zhao B*, Zheng X* and Liu T*. (2021) Proteomics and organoid culture reveal the underlying pathogenesis of Hashimoto’s thyroiditis. Frontiers in Immunology, 12:784975.

 11. Sun S, Jiang N, Jiang Y, He Q, He H, Wang X, Yang L, Li R, Liu F, Lin X* and Zhao B*. (2020) Chromatin remodeler Znhit1 preserves hematopoietic stem cell quiescence by determining the accessibility of distal enhancers. Leukemia (醫(yī)學(xué)1區(qū)Top), 34:3348-3358.

 12. Zhao B*, Ni C, Gao R, Wang Y, Yang L, Wei J, Lv T, Liang J, Zhang Q, Xu W, Xie Y, Wang X, Yuan Z, Liang J*, Zhang R* and Lin X*. (2020) Recapitulation of SARS-CoV-2 infection and cholangiocyte damage with human liver ductal organoids. Protein & Cell (生物1區(qū)Top), 11:771-775. (Highlighted by Nature)

 13. Wang X, Ni C, Jiang N, Wei J, Liang J, Zhao B* and Lin X*. (2020) Generation of liver bipotential organoids with a small-molecule cocktail. Journal of Molecular Cell Biology, 12: 618-629.

 14. Zhao B*, Chen Ying, Jiang N, Yang L, Sun S, Zhang Y, Wen Z, Ray L, Liu H, Hou G and Lin X*. (2019) Znhit1 controls intestinal stem cell maintenance by regulating H2A.Z incorporation. Nature Communications (綜合1區(qū)Top), 10:1071.

 15. Wei J, Ran G, Wang X, Jiang N, Liang J, Lin X*, Ling C* and Zhao B*. (2019) Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors. Journal of Biological Chemistry, 294:14096-14104.

 16. Qi Z, Li Y, Zhao B, Xu C, Liu Y, Li H, Zhang B, Wang X, Yang X, Xie W, Li B, Han JJ and Chen YG. (2017) BMP restricts intestinal Lgr5+ stem cell self-renewal by directly suppressing its signature genes. Nature Communications (綜合1區(qū)Top), 8:13824.

 17. Zhao B, Qi Z, Li Y, Wang C, Fu W and Chen YG*. (2015) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells. Nature Communications (綜合1區(qū)Top), 6:7166.

 18. Lin L, Liu L, Zhao B, Xie R, Lin W, Li H, Li Y, Shi M, Chen YG, Springer TA and Chen X. (2015) Carbon nanotube-assisted optical activation of TGF-β signalling by near-infrared light. Nature Nanotechnology (工程技術(shù)1區(qū)Top), 10:465-71.

 19. Cui HK#, Zhao B#, Li Y, Guo Y, Hu H, Liu L* and Chen YG*. (2013) Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling. Cell Research (生物1區(qū)Top), 23:581-584. (# co-first author)

 20. Zhao B, Wang Q, Du J, Luo S, Xia J and Chen YG*. (2012) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor. Cell Research (生物1區(qū)Top), 22:1467-1478.

 Review Articles:

 1. Li Y, Gao X, Ni C, Zhao B* and Cheng X*. (2023) The application of patient-derived organoid in the research of lung cancer. Cellular Oncology (醫(yī)學(xué)1區(qū)Top), doi.org/10.1007/s13402-023-00771-3.

 2. Wei J, Zhang W and Zhao B*. (2023) Human liver organoid: modeling liver steatosis and beyond. Cell Regeneration, 12:17.

 3. Liang J, Li X, Dong Y and Zhao B*. (2022) Modeling Human Organ Development and Diseases With Fetal Tissue-Derived Organoids. Cell Transplantation, 31:1–15.

 4. Lv T, Meng F, Yu M, Huang H, Lin X and Zhao B*. (2021) Defense of COVID‐19 by Human Organoids. Phenomics,1:113–128.

 5. Zhao B and Chen YG*. (2014) Regulation of TGF-?? Signal Transduction. Scientifica, 2014:874065.