一,、 電子照片

二、簡歷

1,、個人簡歷

孫樂,，女，博士,，副教授,，碩士生導(dǎo)師，云南省免疫學(xué)會中醫(yī)免疫學(xué)分會委員,，云南省轉(zhuǎn)化醫(yī)學(xué)學(xué)會微創(chuàng)外科分會委員,。主持省級科研項目2項，廳級科研項目1項,，參與國家自然科學(xué)基金項目8項,，國家社會科學(xué)基金項目1項，參與國家重點研發(fā)計劃1項,，參與云南省重點實驗室1項,。參與發(fā)表SCI論文17篇，其中第一作者論文3篇,，獲實用新型專利授權(quán)1項,，獲2021年度云南省衛(wèi)生科技成果獎勵三等獎。指導(dǎo)大學(xué)生創(chuàng)新性實驗項目3項,，其中省級1項,，校級2項，指導(dǎo)昆明醫(yī)科大學(xué)第十屆全國大學(xué)生基礎(chǔ)醫(yī)學(xué)創(chuàng)新研究暨實驗設(shè)計論壇大賽校級二等獎一項,，獲2018-2020年度昆明醫(yī)科大學(xué)“三育人”“教書育人先進(jìn)個人”,，昆明醫(yī)科大學(xué)2024年度第五屆全英文課堂教學(xué)比賽一等獎。

2,、聯(lián)系方式

電話：13577009479

電子郵箱：[email protected]

通訊地址：昆明市呈貢區(qū)春融西路1168號

3,、教育經(jīng)歷

2005.09-2008.06 英國倫敦大學(xué)皇家霍洛威學(xué)院 醫(yī)學(xué)生物化學(xué)專業(yè)學(xué)士

2008.09-2009.09英國克菲爾德大學(xué) 分子醫(yī)學(xué)專業(yè)碩士

2011.09-2014.07 北京協(xié)和醫(yī)學(xué)院 免疫學(xué)專業(yè)博士

4、工作經(jīng)歷

2009.09-2010.06 英國劍橋文理學(xué)院坎特伯雷學(xué)院 技術(shù)員

2010.09-2011.06中國醫(yī)學(xué)科學(xué)院醫(yī)學(xué)生物學(xué)研究所 研究實習(xí)員

2014.09-2023.10 昆明醫(yī)科大學(xué) 講師

2023.11-至今 昆明醫(yī)科大學(xué) 副教授

5,、承擔(dān)主要科研項目

1. 云南省科技廳,云南省科技廳昆明醫(yī)科大學(xué)應(yīng)用基礎(chǔ)研究聯(lián)合專項, 202301AY070001-103,豐宮并殖吸蟲ESPs在成蟲肺部寄生過程中的潛在作用機(jī)制研究, 2023-06至20226-05, 10萬元,，項目負(fù)責(zé)人

2. 云南省科技廳,云南省科技廳—昆明醫(yī)科大學(xué)應(yīng)用基礎(chǔ)研究聯(lián)合專項資金青年博士項目, 2017FE467(- 125),利用CRISPR-Cas9技術(shù)對人巨細(xì)胞病毒非編碼區(qū)域定點編輯策略的研究, 2017-07至2021-06, 8萬元,項目負(fù)責(zé)人

3. 云南省教育廳,云南省教育廳科學(xué)研究基金項目, 2015Y179,使用CRISPR-Cas9技術(shù)對人巨細(xì)胞病毒一個miRNA敲除突變株的建立, 2015-10至2017-10, 1萬元,項目負(fù)責(zé)人

6、代表論文,、專利和專著

1. Le Sun#; Min Zhu#; Lei Zhang#; Man Peng; Cuiying Li; Liming Wang; Weiqun Wang; Zhiqiang Ma; Shenghao Li; Weilin Zeng; Min Yin; Wenlin Wang; Weixun Chunyu; Differences in microbiome of healthy Sprague Dawley rats with Paragonimus proliferus infection and potential pathogenic role of microbes in paragonimiasis, Acta Tropica, 2022, 233(106578)

2. Bi Yanwei#;Sun Le#; Gao Dandan; Ding Chen; Li Zhihua; Li Yadong; Cun Wei; Li Qihan; High-efficiency targeted editing of large viral genomes by RNA-guided nucleases., PLoS Pathogens, 2014, 10(5): e1004090-e1004090

3. Sun Le#; Li Qihan; The miRNAs of herpes simplex virus (HSV)., Virol Sin, 2012, 27(6): 333-338

4. Yongzhong Duan#;Le Sun; Qihang Li; Herpes Simplex Virus 1 MicroRNAs: An Update, Intervirology, 2023, 66(1): 97-110

5. Yi Wu#; Lei Ran#; Yue Yang; Xianling Gao; Man Peng; Sida Liu;Le Sun; Jia Wan; Yu Yang; Min Yin; Weixun Chunyu; Deferasirox alleviates DSS-induced ulcerative colitis in inhibiting ferroptosis and improving intestinal microbiota, Life Sciences, 2023, 314: 121312.

6. Man Peng#; Liming Wang; Hui Su; Lei Zhang; Yue Yang;Le Sun; Yi Wu; Lei Ran; Sida Liu; Min Yin; Shude Li; Weixun Chunyu; Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats, Journal of Food Biochemistry, 2022, 46(e14321).

7. Cun, Yina; Li, Chuanyin; Shi, Lei; Sun, Ming; Dai, Shuying;Sun, Le; Shi, Li; Yao, Yufeng; COVID-19 coronavirus vaccine T cell epitope prediction analysis based on distributions of HLA c lass I loci (HLA-A, -B, -C) across global populations, Human Vaccines & Immunotherapeutics, 2020.

8. Dai, Shuying; Li, Chuanyin; Yan, Zhiling; Zhou, Ziyun; Wang, Xia; Wang, Jun;Sun, Le; Shi, Li; Yao, Yufeng; Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population, International Journal of Medical Sciences, 2020, 17(7): 931-938.

9. Li Chuanyin; Wang Xiaona; Li Yingfu; Zhang Xinwen; Sun Mingbo; Liu Shuyuan;Sun Le; Shi Li; Yao Yufeng, Genetic polymorphisms in the TERT gene and susceptibility to non-small cell lung cancer in a Chinese Han population, Cancer Management and Research, 2018, 10: 1487-1495

10. Li Chuanyin; Wang Xiaona; Li Yingfu; Zhang Xinwen; Sun Mingbo; Liu Shuyuan;Sun Le; Shi Li; Yao Yufeng, Genetic polymorphisms in the TERT gene and susceptibility to non-small cell lung cancer in a Chinese Han population, Cancer Management and Research, 2018, 10: 1487-1495

11. Zhihua Li; Yanwei Bi; Hongjian Xiao; Le Sun; Yuan Ren; Yadong Li; Chen Chen; Wei Cun,CRISPR-Cas9 system-driven site-specific selection pressure on Herpes simplex virus genomes,Virus Research,2018, 244: 286-295

12. Weilin Zeng#; Ling Sun#; Zheng Xiang#; Na Li; Jie Zhang; Yongshu He; Qing Li; Fang Yang; Jingling Song; James Morris; Benjamin M. Rosenthal;Le Sun; Huaie Liu; Zhaoqing Yang*, Morphological and molecular characteristics of Sarcocystis bertrami from horses and donkeys in China, Veterinary Parasitology,2018,252:89-94

13. Li, Rongcheng#; Liu, Longding#; Mo, Zhaojun#; Wang, Xuanyi#; Xia, Jielai; Liang, Zhenglun; Zhang, Ying; Li, Yanping; Mao, Qunying; Wang, Jingjing; Jiang, Li; Dong, Chenghong; Che, Yanchun; Huang, Teng; Jiang, Zhiwei; Xie, Zhongping; Wang, Lichun; Liao, Yun; Liang, Yan; Nong, Yi; Liu, Jiansheng; Zhao, Hongling; Na, Ruixiong; Guo, Lei; Pu, Jing; Yang, Erxia;Sun, Le; Cui, Pingfang; Shi, Haijing; Wang, Junzhi; Li, Qihan; An inactivated enterovirus 71 vaccine in healthy children., N Engl J Med, 2014, 370(9): 829-837

14. Yue, Lei, Guo Sujie, Cao Xia, Zhang Ying, Sun Le, Liu Longding, Yan Min, Li Qihan, PNKP knockdown by RNA interference inhibits herpes simplex virus-1 replication in astrocytes, Virol Sin, 2013, 28(6): 345-351

15. Yue Lei, Guo Sujie, Zhang Ying, Liu Longding, Wang Qingling, Wang Xi, Shen Dong, Wang Lichun, Sun Le, Wang Jingjing, Liao Yun, Li Qihan, The modulation of phosphatase expression impacts the proliferation efficiency of HSV-1 in infected astrocytes, PLos One, 2013, 8(11): e79648-e79648

16. Musa Maslinda, Wilson Kirsty, Sun Le, Mulay Apoorva, Bingle Lynne, Marriott Helen M, LeClair Elizabeth E, Bingle Colin D, Differentia l localisation of BPIFA1 (SPLUNC1) and BPIFB1 (LPLUNC1) in the nasal and oral cavities of mice, Cell and Tissue Research, 2012, 350(3): 455-464

17. Yang Erxia, Zhao Heng, Zhang Ying, Liu Jiansheng, Liao Yun, Wang Lichun, Cui Pingfang,Yang Lixian, Liu Longding, Dong Chenghong, Dong Shaozhong, Shao Congwen, Jiang Li, Sun Le, Li Qihan, A comparative study of the characteristics of two Coxsackie A virus type 16 strains (genotype B), Science China Life Sciences, 2012, 55(4): 336-342

18. 孫樂;黃泓泰;李佳懌;彭漫;王謙;張磊;一種巨細(xì)胞病毒一體化核酸檢測裝置, 2021-8-20,中 國, ZL202022310887.8

7,、獲得獎勵

1. 宿主免疫相關(guān)基因及HPV變異與宮頸癌發(fā)生發(fā)展的相關(guān)性和診斷價值,，云南省衛(wèi)生科技成果獎三等獎，嚴(yán)志凌,，戴書穎,，李傳印，楊宏英,，劉舒媛,，張芍，張新文,，楊佳,，孫樂，許金美,，2021年,。