徐祥  研究員

招生層次：碩士/博士研究生

招生專業(yè)：100216康復(fù)醫(yī)學(xué)與理療學(xué)/105500藥學(xué)（專業(yè)學(xué)位）

專業(yè)類型：學(xué)術(shù)型/專業(yè)型

研究方向：干細(xì)胞與再生醫(yī)學(xué)

郵       箱：/[email protected]

個(gè)人簡(jiǎn)介：

1991年09月－1995年07月,，第三軍醫(yī)大學(xué)臨床醫(yī)學(xué)檢驗(yàn)系,，學(xué)士

1998年09月－2002年07月，第三軍醫(yī)大學(xué)野戰(zhàn)外科研究所,，碩士

2003年09月－2006年07月,，第三軍醫(yī)大學(xué)野戰(zhàn)外科研究所,，博士

2007年01月-2009年11月，美國(guó)匹茲堡大學(xué)腫瘤研究所,，訪問(wèn)學(xué)者,，博士后

1995年08月–2000年08月，第三軍醫(yī)大學(xué)野戰(zhàn)外科研究所,，實(shí)習(xí)研究員

2000年08月–2006年08月,，第三軍醫(yī)大學(xué)野戰(zhàn)外科研究所，助理研究員

2006年08月-至今,，第三軍醫(yī)大學(xué)野戰(zhàn)外科研究所,，歷任副研究員、研究員,、主任,，博士研究生導(dǎo)師

主要研究方向及成果：

徐祥教授為重慶英才創(chuàng)新領(lǐng)軍人才，重慶市中青年干細(xì)胞與再生醫(yī)學(xué)卓越團(tuán)隊(duì)帶頭人,。創(chuàng)傷燒傷與復(fù)合傷國(guó)家重點(diǎn)實(shí)驗(yàn)室中心實(shí)驗(yàn)室主任,，陸軍軍醫(yī)大學(xué)陸軍特色醫(yī)學(xué)中心（大坪醫(yī)院）干細(xì)胞與再生醫(yī)學(xué)科主任，中國(guó)醫(yī)藥質(zhì)量管理協(xié)會(huì)細(xì)胞質(zhì)量控制與研究專業(yè)委員會(huì)副主任委員,、中國(guó)醫(yī)藥質(zhì)量管理協(xié)會(huì)細(xì)胞和基因治療藥物質(zhì)量研究專業(yè)委員會(huì)副主任委員,、中國(guó)中西醫(yī)結(jié)合學(xué)會(huì)第一界干細(xì)胞與再生醫(yī)學(xué)專業(yè)委員會(huì)常委和重慶市干細(xì)胞臨床研究專家委員會(huì)委員。長(zhǎng)期從事干細(xì)胞與再生醫(yī)學(xué)基礎(chǔ)與臨床轉(zhuǎn)化應(yīng)用研究,，專注間充質(zhì)干細(xì)胞（MSCs）炎癥/免疫調(diào)節(jié)機(jī)制及臨床轉(zhuǎn)化應(yīng)用治療炎性/免疫相關(guān)性疾病研究,。主持了包括國(guó)家重點(diǎn)研發(fā)計(jì)劃分課題、國(guó)家“973”項(xiàng)目分課題,、國(guó)家自然科學(xué)基金（6項(xiàng)）和省部級(jí)重大研究項(xiàng)目30余項(xiàng),，發(fā)表SCI論文70篇，單篇最高影響因子37.3分,累計(jì)影響因子286分,，第一發(fā)明人獲授權(quán)發(fā)明專利6項(xiàng),，CIK培養(yǎng)基,、NK培養(yǎng)基和臍帶間充質(zhì)干細(xì)胞培養(yǎng)基完成3款I(lǐng)類醫(yī)療器械備案注冊(cè)，以主要完成人獲國(guó)家科技進(jìn)步二等獎(jiǎng)和中華醫(yī)學(xué)科技一等獎(jiǎng)各1項(xiàng),。

代表性論文：

(1) Quan Chen?, Luoquan Ao?, Qing Zhao, Lu Tang, Yanli Xiong, Yuchuan Yuan, Xiaofeng Wu, Zhan Li, Wei Xing, Wei Guo, Xueting Hu, Chengxiu Pu, Huaping Liang,Songguo Zheng, Qizhou Lian, Di Lu, Weijun Wan#,，Xiang Xu#.WTAP/YTHDF1-mediated m6A modification amplifies IFN--induced immunosuppressive properties of human MSCs.J Adv Res.2024,online.（#Corresponding author，IF：11.4）(中科院分區(qū)綜合期刊1區(qū),；JCR綜合期刊Q1)

(2) Zhou Chen,Xuewei Xia, Mengwei Yao,Yi Yang,Xiang Ao,Zhaoqi Zhang,Li Guo,Xiang Xu#.The dual role of mesenchymal stem cells in apoptosis regulation. Cell Death Dis. 2024 Apr 6;15(4):250.（#Corresponding author,，IF：8.1）(中科院分區(qū)生物學(xué)1區(qū)；JCR醫(yī)學(xué)Q1)

(3) Xue-Ting Hu*, Xiao-Feng Wu*, Lu-Min Sui, Luo-Quan Ao, Cheng-Xiu Pu, Mu Yuan, Wei Xing#, Xiang Xu#.The GRHL3-regulated long non-coding RNA lnc-DC modulates keratinocytes differentiation by interacting with IGF2BP2 and up-regulating ZNF750. J Dermatol Sci. 2024 Mar;113(3):93-102.（#Corresponding author,，IF：3.8）(中科院分區(qū)皮膚病學(xué)2區(qū),；JCR皮膚病學(xué)Q1)

(4) Xuewei Xia,Peixin Shen,Guomei Yang,Mengwei Yao,Xiaofeng Wu,Lina Lyn,Yanji He,Zhuxin Li,Wei Wang,Yi Yang,Xiang Ao,Chuanjiang Xia,Zhuo Chen#,Xiang Xu#. The proliferation/migration ability mediated by CD151/PI3K/AKT pathway determines the therapeutic effect of hUC-MSCs transplantation on rheumatoid arthritis. Clinical and Experimental Hypertension.2024 June, 46(1):2366270.（#Corresponding author，IF：1.5）(中科院分區(qū)醫(yī)學(xué)4區(qū),；JCR醫(yī)學(xué)Q4)

(5) Yuan Mu,Hu Xueting,Xing Wei,Wu Xiaofeng,Pu Chengxiu,Guo Wei,Zhu Xiyan,Yao Menwei,Ao Luoquan,Li Zhan,Xu Xiang#. B2M is a biomarker associated with immune infiltration in High altitude pulmonary edema. Comb Chem High Throughput Screen. 2024;27(1):168-185. ( #Corresponding author，IF: 1.6) (中科院分區(qū)醫(yī)學(xué)4區(qū))

(6) Zhuo chen*,Mengwei Yao*,Xiang Xu#,Lingjing Zuo#.The expression mechanism of PD-L1 and its role in immunomodulatory ability of MSCs. Chin J Traumatol. 2024 Jan;27(1):1-10 . ( #Corresponding author,，IF: 1.8) (中科院分區(qū)醫(yī)學(xué)4區(qū))

(7) Chunyan Zhu, Lingjie Ke, Xiang Ao, Ying Chen, Hongwei Cheng, Huhu Xin, Xiang Xu#, Xian-Jun Loh, Zibiao Li, Haiyan Lyu, Qi Wang, Dandan Zhang, Yuan Ping#, Caisheng Wu#, Yun-Long Wu#.Injectable Supramolecular Hydrogels for In Situ Programming of Car-T Cells toward Solid Tumor Immunotherapy. Advanced Materials. 2023 Nov 10:e2310078.doi: 10.1002/adma.202310078. ( #Co-Corresponding author,，IF:27.4) (中科院分區(qū)醫(yī)學(xué)1區(qū)；JCR醫(yī)學(xué)Q1)

(8) Xuewei Xia *, Yongchun Zeng*, Zhuxin Li, Hao Luo Wei Wang, Yanji He, Bingjun Lu, Jingwen Guo, Ken Chen#, Xiang Xu#. Effect of GRK4 on renal gastrin receptor regulation in hypertension, Clinical and Experimental Hypertension, 2023, 45(1), 2245580.（#Corresponding author,，IF：1.5）(中科院分區(qū)醫(yī)學(xué)4區(qū),；JCR醫(yī)學(xué)Q4)

(9) Xiaohui Wang*, Wei Qiu2*, Haoyu Liu, Min He, Wei He, Zhan Li, Zhiqiang Wu, Weidong Han, Xiang Xu#, Ping Chen#.The inducible secreting TLR5 agonist CBLB502 enhances the antitumor activity of CAR133-NK92 cells in colorectal cancer. Cancer Biology & Medicine. 2023 Sep 19;20(9):662-81. ( #Corresponding author，IF: 5.6) (中科院分區(qū)醫(yī)學(xué)2區(qū),；JCR醫(yī)學(xué)Q2)

(10) Weiqiang Li, Qianqian Liu, Jinchao Shi, Xiang Xu#,，Jinyi Xu#. The Role of TNF-αin the Fate Regulation and Functional Reprogramming of Mesenchymal Stem Cells in an Inflammatory Microenvironment. Frontiers in immunology,2023,DOI: 10.3389/fimmu.2023.1074863. ( #Corresponding author，IF: 5.7) (中科院分區(qū)免疫學(xué)2區(qū),；JCR免疫學(xué)Q1)

(11) Shi-Dan Li, Wei Xing, Shao-Chuan Wang, You-Bin Li, Hao Jiang, Han-Xuan Zheng, Xiao-Ming Li, Jing Yang, De-Bin Guo, Xiao-Yu Xie, Ren-Qing Jiang, Chao Fan, Lei Li, Xiang Xu#, Jun Fei#.Fibulin2: a negative regulator of BMSC osteogenic differentiation in infected bone fracture healing. Experimental & Molecular Medicine, 2023, DOI : 10.1038/s12276-023-00942-0. ( #Corresponding author,，IF: 9.5；2022：12.8) (中科院分區(qū)生物化學(xué)與分子生物學(xué)2區(qū),；JCR生物化學(xué)與分子生物學(xué)Q1)

(12) Yu Wang, Xia Zhou, Shunyao Zhu, Xinlin Wei, Nazi Zhou, Xueyuan Liao, Yanhua Peng, Yaping Tang, Lin Zhang, Xi Yang, Yang Li, Xiang Xu#, Jie Tao#, Rui Liu#. Cryoprinting of Nanoparticle-Enhanced Injectable Hydrogel with Shape-memory properties. Materials & Design 223 (2022) 111120. ( #Co-Corresponding author,，IF: 8.4) (中科院分區(qū)材料科學(xué)1區(qū)；JCR材料科學(xué)Q1)

(13) Mengwei Yao,Zhuo Chen, Xiao He,Jiaoyue Long, Xuewei Xia, Zhan Li,Yu Yang, Luoquan Ao,Wei Xing,Qizhou Lian,Huaping Liang#, Xiang Xu#. Cross talk between glucose metabolism and immunosuppression in IFN--primed mesenchymal stem cells. Life Science Alliance.2022;5(12):e202201493. ( #Corresponding author,，IF: 4.4) (中科院分區(qū)生物學(xué)2區(qū),；JCR細(xì)胞生物學(xué)Q1)

(14) Xiao-hui Wang*, Wei Guo*, Wei Qiu*, Luo-quan Ao, Meng-wei Yao,Wei Xing,Yang Yu, Quan Chen, Xiao-feng Wu, Zhan Li, Xue-ting Hu#,Xiang Xu#. Fibroblast-like cells Promote Wound Healing via PD-L1-mediated Inflammation Resolution. International Journal of Biological Sciences.2022;18:4388-4399. ( #Corresponding author，IF: 9.2) (中科院分區(qū)生物大類2區(qū),；JCR細(xì)胞生物學(xué)Q1)

(15) Li Shidan,Jiang Hao,Xing Wei,Wang Shaochuan,Zhang Yao,Li Youbin,Mao Chengyi,Zeng Delian,Lan Ping,TangDongqin,Zhan Jijie,Li Lei,Xu Xiang#,Fei Jun#.A Clinical Diagnostic Study: Fibulin-2 is a Novel Promising Biomarker for Predicting Infection. Infect Dis Ther. 2022 Mar 18. pii: 10.1007/s40121-022-00622-y. (#Corresponding author,，IF: 5.4) (中科院分區(qū)醫(yī)學(xué)大類3區(qū)；JCR傳染病學(xué)Q1)

(16) Weijun Wang*,Xiang Ao*, Quang Chen, Yang Yu, Luoquan Ao, Luming Sui,Mengwei Yao,Wei Xing, Xiaofen Wu, Zhan Li, Xueting Hu, Wei Guo, Donglin Luo#,Xiang Xu#. METTL3/IGF2BP3 axis inhibits tumor immune surveillance by upregulating N6-methyladenosine modification of PD-L1 mRNA in breast cancer. Mol Cancer. 2022 Feb 23;21(1):60. doi: 10.1186/s12943-021-01447-y.(#Corresponding author,，IF: 37.4) (中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR腫瘤學(xué)Q1)（Cited:24）

(17) Yi Yang*, Xiao He*, Mengwei Yao, Wei Xing, Luoquan Ao, Joseph A. Bellanti, Songguo Zheng, Xiang Xu#. Response to:‘Correspondence to:‘Combination of human umbilical cord mesenchymal stem cell transplantation with IFN-γtreatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis’’by Ma et al. Ann Rheum Dis. 2022 Oct;81(10):e207. doi: 10.1136/annrheumdis-2020-218762. ( Corresponding author，IF:27.4) (中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR免疫學(xué)Q1)

(18) Zhengcheng Wang*,Xiang Ao*, Zhilin Shen,Luoquan Ao,Xiaofeng Wu,Wei Guo,Wei Xiang,Min He, Hongfeng Yuan, Jianhua Yu, Ling Li#, Xiang Xu#. TNF-αaugments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell. International Journal of Biological Sciences.2021; 17(11): 2683-2702. ( #Corresponding author,，IF: 10.75) (中科院分區(qū)生物大類2區(qū),；JCR細(xì)胞生物學(xué)Q1)（Cited:32）

(19) Xiao He*, Yi Yang*, Mengwei Yao, Lei Yang, Luoquan Ao, Xueting Hu, Zhan Li, Xiaofeng Wu, Yan Tan, Wei Xing, Wei Guo, Joseph A. Bellanti, Songguo Zheng#, Xiang Xu#. Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-γtreatment synergistically improves the clinical outcomes of rheumatoid arthritis patients. Ann Rheum Dis.2020, Oct;79(10):1298-1304. ( #Corresponding author，IF: 27.4) (中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR免疫學(xué)Q1) ( Cited:30)

(20) Zhan Li, Yuqing Song, Peisong Yuan, Wei Guo, Xueting Hu, Wei Xing, Luoquan Ao, Yan Tan, Xiaofeng Wu, Xiang Ao, Xiao He, Dongpo Jiang#, Huaping Liang#, xiang xu#. Antibacterial fusion protein BPI21/LL-37 modification enhances the therapeutic efficacy of human umbilical cord mesenchymal stem cells in sepsis. Mol Ther. 2020 May 15. pii: S1525-0016(20)30248-3. doi: 10.1016/j.ymthe.2020.05.014.(#Corresponding author,，IF:11.45) (中科院分區(qū)醫(yī)學(xué)大類1區(qū)；JCR醫(yī)學(xué)Q1)（Cited:3）

(21) Xue-ting Hu*; Wei Xing*; Rong-sen Zhao; Yan Tan; Xiao-feng Wu; Luo-quan Ao; Zhan Li; Meng-wei Yao; Mu Yuan; Wei Guo; Shang-ze Li; Jian Yu; Xiang Ao#; Xiang Xu#.HDAC2 inhibits EMT-mediated cancer metastasis by downregulating the long noncoding RNA H19 in colorectal cancer. Journal of Experimental & Clinical Cancer Research,2020,39(1):270. ( # Corresponding author,，IF: 11.16)  (中科院JCR分區(qū)醫(yī)學(xué)大類1區(qū),；JCR腫瘤學(xué)Q1)（Cited:68）

(22) Xuanfei Li,Junyu Zhu,Lixing Tian,Xiaoyuan Ma,Xia Fan,Li Luo,Jing Yu,Yu Sun,Xue Yang,Wanqi Tang,Wei Ma,Jun Yan, Xiang Xu#,Huaping Liang#. Agmatine protects against the progression of sepsis through the imidazoline I2 receptor-RSK2-NF-kB signaling pathway. Crit Care Med. 2020,48(1):e40-e47. (#Corresponding author，IF:7.598) (中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR危重病醫(yī)學(xué)Q1)（Cited:7）

(23) Wei Guo*, Wei Qiu*,Xiang Ao*, Xiao He,Tian-chen An, Luo-quan Ao, Xue-ting Hu, Zhan Li, Ming Zhu,Xiangyun Li,Wei Xing#,Xiang Xu#. Low-concentration DMSO accelerates skin wound healing by AKT/mTOR-mediated cell proliferation and migration in diabetic mice. BRIT J PHARMACOL,，2020，Jul;177(14):3327-3341.(#Corresponding author,，IF: 8.739) (中科院分區(qū)藥理學(xué)1區(qū),；JCR藥理學(xué)Q1)（Cited:10）

(24) Xiao-hui Wang, Zhi-qiang Wu, Wei Qiu, Ping Chen, Xiang Xu#, Wei-dong Han#. Programming CAR T cells to enhance antitumor efficacy through remodeling of the immune system. Frontiers of Medicine. 2020 Aug 13. pii: 10.1007/s11684-020-0746-0. (#Corresponding author，IF: 4.592) (中科院分區(qū)醫(yī)學(xué)大類3區(qū),；JCR醫(yī)學(xué)Q1) ( Cited:7)

(25) J Li,Q.S Ran,B Hao,X Xu#,H.F Yuan#.Transsphenoidal optic canal decompression for traumatic optic neuropathy assited by a computed tomography image postprocessing Technique.Journal of Ophthalmology. 2020 Aug 12;2020:1870745. (#Corresponding author,，IF: 1.909) (中科院JCR分區(qū)醫(yī)學(xué)大類4區(qū)；JCR醫(yī)學(xué)Q3)（Cited:2）

(26) Jia Li,Xu Bai, Xiaoyue Guan, Hongfeng Yuan#, Xiang Xu#. Treatment of optic canal decompression combined with umbilical cord mesenchymal stem (stromal) cells for indirect traumatic optic neuropathy: a phase 1 clinical trial. Ophthalmic Research. 2021;64(3):398-404. ( #Corresponding author,，IF:2.892) (中科院分區(qū)醫(yī)學(xué)大類4區(qū),；JCR眼科學(xué)Q3)（Cited:1）

(27) Xiao he; Meng-Wei Yao; Ming Zhu; Dong-Lan Liang; Wei Guo; Yi Yang; Rong-Seng Zhao; Ting-Ting Ren; Xiang Ao; Wei Wang; Chun-Yu Zeng; Hua-Ping Liang; Dong-po Jiang; Jian Yu; xiang xu#. High glucose protects mesenchymal stem cell from metformin-induced apoptosis through AMPK-mediated mTOR pathway. Scientific Reports, (2019) 9:17764 | https://doi.org/10.1038/s41598-019-54291-y. (#Corresponding author，IF:3.998) (中科院分區(qū)綜合期刊3區(qū),；JCR綜合分區(qū)Q1) ( Cited:5)

(28) Xiang Ao, Yu Yang, Weiqiang Li, Yan Tang,Wei Qiu, Luo-quan Ao, Xue-ting Hu, Zhan Li, Xiao-Feng Wu, Xiao He, Jianchuan Xia, Xiang Xu#,Jian-xing Guo#. Anti-αFR CAR-engineered NK-92 cells display potent cytotoxicity againstαFR-positive ovarian cancer. Journal of Immunotherapy,2019, 42(8):284-296. (#Co-Corresponding author,，IF:4.11) (中科院分區(qū)醫(yī)學(xué)大類2區(qū)；JCR免疫學(xué)Q2) ( Cited:34)

(29) Xiao he; Meng-Wei Yao; Ming Zhu; Dong-Lan Liang; Wei Guo; Yi Yang; Rong-Seng Zhao; Ting-Ting Ren; Xiang Ao; Wei Wang; Chun-Yu Zeng; Hua-Ping Liang; Dong-po Jiang; Jian Yu; xiang xu#. Metformin induces apoptosis in mesenchymal stem cells and dampens their therapeutic efficacy in infarcted myocardium. Stem Cell Research & Therapy,，2018,，9:306.https://doi.org/10.1186/s13287-018-1057-0. # Corresponding author ,IF: 4.627) (中科院分區(qū)醫(yī)學(xué)大類2區(qū)；JCR細(xì)胞生物學(xué)Q1) ( Cited:14)

(30) Daqian Gu; Xiang Ao; Yu Yang; Zhuo Chen; Xiang Xu#. Soluble Immune Checkpoints in Cancer: Production, Function and Biological Significance. J Immunother Cancer. 2018 Nov 27;6(1):132. doi: 10.1186/s40425-018-0449-0. (#Corresponding author,IF:8.676)(中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR免疫學(xué)Q1) (Cited:121次)

(31) Xiao He,Shanmu Ai,Wei Guo,Yi Yang,Zhengguo Wang,Dongpo Jiang#,Xiang Xu#.Umbilical cord-derived mesenchymal stem (stromal) cellsfor treatment of severe sepsis:a phase 1 clinical trial. Transl Res. 2018 Sep;199:52-61. (#Corresponding author,IF:4.915)（中科院分區(qū)醫(yī)學(xué)實(shí)驗(yàn)技術(shù)1區(qū);JCR醫(yī)學(xué)Q1）(Cited:32次)

(32) Yi Yang; Xiao He; Rongseng Zhao; Wei Guo; Ming Zhu; Wei Xing; Dongpo Jiang; Chongyang Liu#; xiang xu#.Serum IFN-γLevels Predict the Therapeutic Effect of Mesenchymal Stem Cell Transplantation in Active Rheumatoid Arthritis . J Transl Med. 2018 Jun 15;16(1):165. doi: 10.1186/s12967-018-1541-4. (#Corresponding author, IF:4.098)（中科院分區(qū)醫(yī)學(xué)大類2區(qū),；JCR醫(yī)學(xué)Q2）(Cited:25次)

(33) M Zhu, X He, X-h Wang, W Qiu, W Xing, W Guo, T-c An, L-q Ao, X-t Hu, Z Li, X-p Liu, N Xiao, J Yu, H Huang#, X Xu#. Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications. Diabetologia. 2017 Sep;60(9):1822-1833. doi: 10.1007/s00125-017-4316-1. Epub 2017 Jun 3. ( #Corresponding author,IF:6.08) (中科院分區(qū)醫(yī)學(xué)大類1區(qū)；JCR醫(yī)學(xué)Q1)(Cited:16次)

(34) Li X,，Li M,，Ruan H，Qiu W,，Xu X#,，Zhang L，Yu J#. Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress. Oncotarget,2017,8(6):9280-9292. (#Corresponding author,IF:5.128) (Cited:9次)

(35) Ming Zhu, Wen-Qiu Huang, Wei Qiu, Fang-Qiang Zhu, Wei Xing, Min-Jia Chen, Tian-Chen An, Luo-Quan Ao, Xiang Xu#, Hong Huang#.Curcumin protects mesenchymal stem cells against oxidative stress-induced apoptosis via Akt/mTOR/p70S6K pathway. International Journal of Clinical and Experimental Pathology, 2017, 10(6): 6655-6664.( #Corresponding author,，IF:1.396) (中科院分區(qū)醫(yī)學(xué)大類4區(qū),；JCR醫(yī)學(xué)Q4)

(36) Jiaoyan Han, Jiao Song, Xiangyun Li, Ming Zhu, Wei Guo, Wei Xing, Rongshen Zhao, Xiao He, Xiaoping Liu, Shali Wang, Yunyun Li, Hong Huang#, Xiang Xu#. Ligustrazine Suppresses the Growth of HRPC Cells through the Inhibition of Cap-Dependent Translation Via Both the mTOR and the MEK/ERK Pathways.Anti-Cancer Agents in Medicinal Chemistry.2015;15(6):764-772. (#Corresponding author，IF:2.722) (中科院分區(qū)醫(yī)學(xué)大類3區(qū),；JCR醫(yī)學(xué)Q3)(cited：16次)

(37) Wei Xing&, Wei Guo&, Cun-Hua Zou,Ting-Ting Fu, Xiang-Yun Li, Ming Zhu, Jun-Hua Qi, Jiao Song, Chen-Hui Dong, Zhuang Li, Yong Xiao, Pei-Song Yuan, Hong Huang#, Xiang Xu#.Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J Dermatol Sci. 2015 Aug;79(2):101-9. doi: 10.1016/j.jdermsci.2015.03.016. (#Corresponding author,IF:3.739) (中科院分區(qū)醫(yī)學(xué)大類2區(qū),；,；JCR皮膚病Q1) (cited：52次)

(38) Hong Huang,Wenhui Cui,Wei Qiu, Ming Zhu, Rongshen Zhao, Dengfen Zeng, Chenhui Dong,Xiaohui Wang, Wei Guo,Wei Xing,Xiangyun Li, Lei Li, Yan Tan, Xiaofeng Wu, Lizhao Chen,Xiaobing Fu,Donglin Luo, Xiang Xu#.Impaired wound healing results from the dysfunction of the Akt/mTOR pathway in diabetic rats. J Dermatol Sci.2015 Sep;79(3):241-51. doi: 10.1016/j.jdermsci.2015.06.002. Epub 2015 Jun 10(#Corresponding author,IF:3.739) (中科院分區(qū)醫(yī)學(xué)大類2區(qū)；JCR皮膚病Q1) ( cited:26次)

(39) Chen Li-zhao*,，Li Xiang-yun*,，Huang Hong，Xing Wei,，Guo Wei,，He Jing，Sun Zhi-ya,，Luo An-xiong,，Liang Hua-ping，Hu Jing,，Xu Yun-sheng#,，Wang Zheng-guo#，Xu Xiang#. SUMO-2 promotes mRNA translation by enhancing interaction between eIF4E and eIF4G. PLoS One. 2014 Jun 27;9(6):e100457. doi: 10.1371/journal.pone. 0100457.( #Corresponding author,，IF: 3.534) (中科院分區(qū)綜合科學(xué)3區(qū),；JCR綜合科學(xué)Q2) (cited:7)

(40) Hong-Feng Yuan*, Hong Huang*, Xiang-Yun Li, Wei Guo, Wei Xing, Zhi-Ya Sun, Hua-Ping Liang, Jian Yu, Dong-Feng Chen, Zheng-Guo Wang, Jin Hao#,Xiang Xu#. A Dual AP-1 and SMAD Decoy ODN Suppresses Tissue Fibrosis and Scarring in Mice. Journal of Investigative Dermatology, 2013;133(4):1080-7. (#Corresponding author，IF:6.372) (中科院分區(qū)皮膚病學(xué)1區(qū),；JCR皮膚病Q1) (cited:15)

(41) Xiang Xu*,Fangqiang Zhu*,Meng Zhang,Dengfen Zeng,Donglin Luo,Guodong Liu,Wenhui Cui,Shali Wang,Wei Guo,Wei Xing,Huaping Liang,Lei Li,Xiaobing Fu,Jianxin Jiang,Hong Huang. Stromal Cell-Derived Factor-1 Enhances Wound Healing through Recruiting Bone Marrow-Derived Mesenchymal Stem Cells to the Wound Area and Promoting neovascularization. Cells Tissues Organs, 2013;197:103–113. (*Co-First author,IF:2.138) (中科院分區(qū)生物學(xué)4區(qū)；JCR解剖學(xué)Q2) (cited:105)

(42) Li Na*,，Xu Xiang*,，Xiao Bin, Zhu En-Dong，Li Bo-Sheng,，Liu Zhen,，Tang Bin，Zou Quan-Min,，Liang Hua-Ping,，Mao Xu-Hu. H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. Molecular Biology Reports. 2012;39(4):4655-61.(*Co-first author,IF:2.506) (中科院JCR分區(qū)生物學(xué)4區(qū)；JCR生物學(xué)Q4) (cited:53)

(43) Yu Fu Wang*, Xiang Xu*, Xia Fan, Chun Zhang, Qiang Wei, Xi Wang, Wei Guo,Wei Xing, Jian Yu, Jing-Long Yan and Hua-Ping Liang.A Cell-penetrating Peptide Suppresses inflammation by Inhibiting  NF-κB Signaling, Molecular Therapy, 2011;19（10）：1849-57.（*Co-first author,IF:6.873）(中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR醫(yī)學(xué)Q1) (cited:46)

(44) Xiang Xu*, Jaya Vatsyayan*, Chenxi Gao,Christopher J.Bakkenist,and jing Hu. Sumoylation of eIF4E activates mRNA translation. EMBO Reports,2010; 11(4): 299-304.（*Co-first author,IF:7.822）(中科院分區(qū)醫(yī)學(xué)大類1區(qū),；JCR醫(yī)學(xué)Q1) (cited:41)

(45) Xiang Xu*, Jaya Vatsyayan*, Chenxi Gao,Christopher J.Bakkenist,and jing Hu.HDAC2 promotes eIF4E sumolation and activates mRNA translation gene specifically. JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(24):18139-18143.（*Co-first author,IF:5.328）(中科院分區(qū)生物學(xué)2區(qū)；JCR生物化學(xué)Q1) (cited:31)

代表性授權(quán)發(fā)明專利：

(1) 徐祥,；梁華平,；王正國(guó).核因子-kB p50亞基拮抗肽及其制備與應(yīng)用，中國(guó)發(fā)明專利,，專利號(hào)：200510069461.5（2006.12.27授權(quán)）,。（第一發(fā)明人）

(2) 徐祥；梁華平,；王正國(guó).核因子-kB p65亞基拮抗肽及其應(yīng)用,，中國(guó)發(fā)明專利,，專利號(hào)：200510007479.2（2007.3.14授權(quán)）。（第一發(fā)明人）

(3) 梁華平,；徐祥,；王正國(guó).核因子-kB p50亞基結(jié)合肽及其制備與應(yīng)用，中國(guó)發(fā)明專利,，專利號(hào)：200510069428.2（2007年授權(quán)）,。（第二發(fā)明人）

(4) 梁華平；徐祥,；王正國(guó).核因子-kB p65亞基結(jié)合肽及其制備與應(yīng)用,，中國(guó)發(fā)明專利，專利號(hào)：200510069451.1（2007年授權(quán)）,。（第二發(fā)明人）

(5) 徐祥,；袁洪峰；黃宏,；郭韡,；邢偉；梁華平.新型雙功能抗瘢痕和組織纖維化藥物,，中國(guó)發(fā)明專利,，專利號(hào)：201110001699.x(2013年1月2號(hào)授權(quán))（第一發(fā)明人）

(6) 徐祥；郭韡,；邢偉,；黃宏；羅安雄,；陳東風(fēng).抗瘢痕和組織纖維化寡聚雙鏈核苷酸藥物及其應(yīng)用,中國(guó)發(fā)明專利,，專利號(hào)：201310089302.6。（第一發(fā)明人,，2015年7月22日授權(quán)）

(7) 敖羅權(quán),，徐祥，敖翔,。靶向葉酸受體α嵌合抗原受體,、其制備方法及其應(yīng)用，中國(guó)發(fā)明專利,，202111163687.7

(8) 徐祥,，敖翔，敖羅權(quán),。一種基于假attP位點(diǎn)自發(fā)定向整合的通用型微環(huán)DNA表達(dá)載體及其構(gòu)建方法與應(yīng)用,，中國(guó)發(fā)明專利，202110801525.5，授權(quán)日：2023.12.15,。

(9) 周興,，徐祥，張成元,，李子黎,，袁玉川。一種高效低毒的自組裝陽(yáng)離子納米粒及制備方法和應(yīng)用,，中國(guó)發(fā)明專利,，202111181976.X

(10) 徐祥,夏雪偉,姚孟維,李戰(zhàn),閭開(kāi)顏。CD83+,、CD83+PD-L1+間充質(zhì)干細(xì)胞及其制備方法和應(yīng)用,，中國(guó)發(fā)明專利，2023115505347,，申請(qǐng)日：2023.11.21,。

(11) 徐祥,夏雪偉,姚孟維,李戰(zhàn),閭開(kāi)顏。CD83+,、CD83+PD-L1+間充質(zhì)干細(xì)胞及其制備方法和應(yīng)用,，國(guó)際（美日歐），PCT/CN2023/135087,，申請(qǐng)日：2023.12.6,。