廖玉輝,，國(guó)家優(yōu)青,，國(guó)家重點(diǎn)研發(fā)計(jì)劃首席科學(xué)家，廣東省杰青,，昆明醫(yī)科大學(xué)高層次人才(第二層次：領(lǐng)軍人才),、醫(yī)工交叉研究院院長(zhǎng)、科技處處長(zhǎng),。研究團(tuán)隊(duì)圍繞高靈敏度功能探針構(gòu)建及重大疾病標(biāo)志物的定量分析開(kāi)展研究,，建立了病灶特異的功能探針，實(shí)現(xiàn)了重大傳染病診斷,、治療新策略(Nature Nanotechnology, IF=38.3; Advanced Materials 2篇, IF=29.4; Matter, IF=18.9; Aggregate 2篇, IF= 18.8; ACS Nano 2篇, IF=17.1),；設(shè)計(jì)了信號(hào)放大探針，實(shí)現(xiàn)了傳染病病原體實(shí)時(shí)監(jiān)測(cè)及普適性標(biāo)志物檢測(cè)(Nature Protocols, IF=14.8; ACS Central Science, IF=18.2; Theranostics, IF=12.4; ACS Nano, IF=17.1),；構(gòu)建了靶標(biāo)觸發(fā)的功能探針,，應(yīng)用于病灶在體成像診斷及高靈敏度液體活檢新模式(Advanced Materials 2篇, IF=29.4; Bioactive Materials, IF=18.9; Angewandte Chemie, IF= 16.6; Small 2篇, IF=13.3; Redox Biology, IF=11.4; Journal of Controlled Release, IF=10.8)。已發(fā)表論文40篇，其中IF>10的19篇,，ESI熱點(diǎn)論文4篇,，ESI高被引論文9篇，SCI一區(qū)論文30篇,，他引1000次以上,，單篇引用最高155次，H指數(shù)為24,，i10指數(shù)為34,；主持國(guó)家重點(diǎn)研發(fā)計(jì)劃1項(xiàng)，國(guó)家自然科學(xué)基金項(xiàng)目4項(xiàng),，廣東省自然科學(xué)基金杰出青年項(xiàng)目1項(xiàng),，申請(qǐng)國(guó)家發(fā)明專利30項(xiàng)、授權(quán)12項(xiàng),。任中國(guó)中西醫(yī)學(xué)會(huì)傳染病專業(yè)委員會(huì)青年委員,，中國(guó)檢驗(yàn)裝備學(xué)會(huì)檢驗(yàn)醫(yī)學(xué)分會(huì)委員，廣東省青年科學(xué)家協(xié)會(huì)會(huì)員,，廣東省醫(yī)學(xué)會(huì)放射醫(yī)學(xué)分會(huì)分子影像學(xué)組委員,，廣東省精準(zhǔn)醫(yī)學(xué)應(yīng)用學(xué)會(huì)長(zhǎng)青人智庫(kù)委員會(huì)委員?？烧惺障嚓P(guān)專業(yè)的碩博研究生,。

電子郵箱：[email protected]

個(gè)人簡(jiǎn)歷：

2024年5月-至今 昆明醫(yī)科大學(xué)高層次人才(第二層次：領(lǐng)軍人才)醫(yī)工交叉研究院院長(zhǎng) 科技處處長(zhǎng)

2019年4月-2024年4月 南方醫(yī)科大學(xué)高層次人才(優(yōu)秀青年學(xué)者)研究員

2017年6月-2018年11月 中山大學(xué) 中山醫(yī)學(xué)院 免疫學(xué)教研室 診斷組負(fù)責(zé)人 特聘副研究員

2016年7月-2017年1月 華南師范大學(xué) 生物光子學(xué)研究院 師資博士后

2011年9月-2016年6月 華南師范大學(xué) 生物光子學(xué)研究院 博士

2010年7月-2011年8月 中國(guó)科學(xué)院 昆明植物研究所 技術(shù)員

2006年9月-2010年6月 西南科技大學(xué) 生命科學(xué)與工程學(xué)院 學(xué)士

主要項(xiàng)目：

1)國(guó)家重點(diǎn)研發(fā)計(jì)劃，青年科學(xué)家項(xiàng)目,，2022-01至2024-12,，1300萬(wàn)元，在研,，主持,；

2)國(guó)家自然科學(xué)基金委員會(huì)，優(yōu)秀青年科學(xué)基金項(xiàng)目,，2024-01至2026-12,200萬(wàn)元,，在研，主持,；

3)廣東省基礎(chǔ)與應(yīng)用基礎(chǔ)研究基金自然科學(xué)基金,，杰出青年項(xiàng)目,2022-01至2025-12,，150萬(wàn)元,，在研，主持,；

4)國(guó)家自然科學(xué)基金委員會(huì),，面上項(xiàng)目，2023-01至2026/12，52萬(wàn)元,，在研,，主持；

5) 國(guó)家自然科學(xué)基金委員會(huì),，面上項(xiàng)目,，2020-01至2023/12，55萬(wàn)元,，在研,，主持；

6) 國(guó)家自然科學(xué)基金委員會(huì),，青年科學(xué)基金項(xiàng)目,，2020-01至2022-12，24.5萬(wàn)元,，結(jié)題,，主持。

近期代表性成果：

2024年

1. Fu Y, Chen X, Song W, et al. Light-Switch Electrochemiluminescence-Driven microfluidic sensor for rapid and sensitive detection of Mpox virus[J]. Chemical Engineering Journal, 2024, 498: 154930.

2. Yang H, Zheng J, Wang W, et al. Zr-MOF carrier-enhanced dual-mode biosensing platforms for rapid and sensitive diagnosis of mpox[J]. Advanced Science, 2024, 11(38): 2405848.

3. Yang Z, Su J, Wang J, et al. Spin-coating fabrication of high‐yield and uniform organic thin‐film transistors via a primer template growth[J]. Aggregate, 2024: e661.

4. Wang H, Li B, Sun Y, et al. NIR‐II AIE Luminogen‐Based Erythrocyte-Like Nanoparticles with Granuloma‐Targeting and Self‐Oxygenation Characteristics for Combined Phototherapy of Tuberculosis[J]. Advanced Materials, 2024, 36(38): 2406143.

5. Zhao M, Kang M, Wang J, et al. Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing[J]. Advanced Materials, 2024: 2401369.

6. Wang W, Li B, Wu Y, et al. Macrophage-derived biomimetic nanoparticles for light-driven theranostics toward Mpox[J]. Matter, 2024, 7(3): 1187-1206.

7. Guan H, Wang W, Jiang Z, et al. Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic–Angiogenic Coupling for Osteoporotic Bone Repair[J]. Advanced Materials, 2024, 36(13): 2312081.

8. Li B, Wang W, Zhao L, et al. Aggregation‐induced emission-based macrophage‐like nanoparticles for targeted photothermal therapy and virus transmission blockage in Monkeypox[J]. Advanced Materials, 2024, 36(9): 2305378.

9. Li B, Wang W, Zhao L, et al. Photothermal therapy of tuberculosis using targeting pre-activated macrophage membrane-coated nanoparticles[J]. Nature Nanotechnology, 2024: 1-12.

10. Chen X, Zhao M, Xie Q, et al. Click‐hydrogel delivered aggregation‐induced emissive nanovesicles for simultaneous remodeling and antibiosis of deep burn wounds[J]. Aggregate, 2024, 5(1): e406.

11. Wu T, Fu Y, Guo S, et al. Self-assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic-resistant bacteria[J]. Aggregate, 2024, 5(1): e402.

12. Zheng J, Chen T, Wang K, et al. Engineered multifunctional zinc-organic framework-based aggregation-induced emission nanozyme for accelerating spinal cord injury recovery[J]. ACS nano, 2024, 18(3): 2355-2369.

13. Wang W, Wang J, Hu Z, et al. Advancing Aggregation‐Induced Emission‐Derived Biomaterials in Viral, Tuberculosis, and Fungal Infectious Diseases[J]. Aggregate, 2024: e715.

14. Li X, Wang W, Gao Q, et al. Intelligent bacteria-targeting ZIF-8 composite for fluorescence imaging‐guided photodynamic therapy of drug-resistant superbug infections and burn wound healing[C]//Exploration. 2024: 20230113.

15. Lin W, Shen C, Li M, et al. Programmable Macrophage Vesicle Based Bionic Self‐Adjuvanting Vaccine for Immunization against Monkeypox Virus[J]. Advanced Science, 2024: 2408608.

16. Fan Z, Liu Y, Ye Y, et al. Functional probes for the diagnosis and treatment of infectious diseases[J]. Aggregate, 2024: e620.

17. Zhang D, Tian B, Ling Y, et al. CRISPR/Cas12a-Powered Amplification-Free RNA Diagnostics by Integrating T7 Exonuclease-Assisted Target Recycling and Split G-Quadruplex Catalytic Signal Output[J]. Analytical Chemistry, 2024.

2023年

1. Ji Z, Zheng J, Ma Y, et al. Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual-Signal Transform-Based Selenium Antioxidant. Small. 2023;19(35):e2207888.

2. Guan H, Wang W, Jiang Z, et al. Magnetic Aggregation-Induced Bone-Targeting Nanocarrier with Effects of Piezo1 Activation and Osteogenic-Angiogenic Coupling for Osteoporotic Bone Repair. Adv Mater. 2024;36(13):e2312081.

3. Li B, Wang W, Zhao L, et al. Multifunctional AIE Nanosphere-Based "Nanobomb" for Trimodal Imaging-Guided Photothermal/Photodynamic/Pharmacological Therapy of Drug-Resistant Bacterial Infections.ACS Nano. 2023;17(5):4601-4618.

4. Wu T , Fu Y , Guo S ,et al.Self‐assembly multifunctional DNA tetrahedron for efficient elimination of antibiotic‐resistant bacteria[J].Aggregate, 2024, 5(1): e402

5. Wu T, Wang H, Tian R, et al. A DNA Origami-based Bactericide for Efficient Healing of Infected Wounds. Angew Chem Int Ed Engl. 2023;62(46):e202311698.

6. Lin W, Huang J, Guo S, et al. A tunable fluorescent probe for superoxide anion detection during inflammation caused by Treponema pallidum. J Mater Chem B. 2023;11(20):4523-4528.

7. Fu Y, Zeng L, Huang P, et al. Severity-onset prediction of COVID-19 via artificial-intelligence analysis of multivariate factors. Heliyon. 2023;9(8):e18764.

8. Peng C, Luo J, Wang K, et al. Iridium metal complex targeting oxidation resistance 1 protein attenuates spinal cord injury by inhibiting oxidative stress-associated reactive oxygen species. Redox Biol. 2023;67:102913.

9. Huang J, Jiang Y, Lin W, et al. Virulence and Adhesion of the Treponema pallidumNichols Strain Simultaneously Decrease in a Continuous-Infection New Zealand White Rabbit Model. ACS Infect Dis. 2023;9(6):1221-1231.

10. Fu Y, Liu Y, Song W, et al. Early monitoring-to-warning Internet of Things system for emerging infectious diseases via networking of light-triggered point-of-care testing devices. Exploration (Beijing). 2023;3(6):20230028.

2022年

1. Fan Z, Wang Y, Li L, et al. Tumor-Homing and Immune-Reprogramming Cellular Nanovesicles for Photoacoustic Imaging-Guided Phototriggered Precise Chemoimmunotherapy [published correction appears in ACS Nano. 2023 Feb 14;17(3):3204.

2. Yang W, Yang G, Li MY, Liu ZY, Liao YH, Liu HY. Photodynamic antitumor activity of Gallium(III) and Phosphorus(V) complexes of trimethoxyl A2B triaryl corrole. Bioorg Chem. 2022;129:106177.

3. Liu C, Wang Y, Li L, et al. Engineered extracellular vesicles and their mimetics for cancer immunotherapy. J Control Release. 2022;349:679-698.

4. Wu Y, Yang R, Wu Q, et al. Trace Analysis of Emerging Virus: An Ultrasensitive ECL-Scan Imaging System for Viral Infectious Disease. ACS Omega. 2022;7(42):37499-37508.

5. Li Z , Teng M , Yang R ,et al.Sb-doped WO3 based QCM humidity sensor with self-recovery ability for real-time monitoring of respiration and wound[J].Sensors and Actuators B: Chemical, 2022, 361:131691.

6. Li Z, Teng M, Jiang Y, et al. YTHDF1 Negatively Regulates Treponema pallidum-Induced Inflammation in THP-1 Macrophages by Promoting SOCS3 Translation in an m6A-Dependent Manner. Front Immunol. 2022;13:857727.