姓        名：袁云

出生年月：1979年7月

碩導(dǎo)/博導(dǎo)：碩士研究生導(dǎo)師

學(xué)        位：碩士研究生

所屬科室：基礎(chǔ)醫(yī)學(xué)院 人體解剖學(xué)與組織胚胎學(xué)系

職        務(wù)：無(wú)

郵        箱：[email protected]

所獲獎(jiǎng)項(xiàng)：昆明醫(yī)科大學(xué)百名中青年學(xué)術(shù)和技術(shù)骨干 優(yōu)秀指導(dǎo)教師

招生專業(yè)：人體解剖與組織胚胎學(xué)

研究領(lǐng)域：缺血缺氧性腦損傷及天然藥物干預(yù)

社會(huì)兼職：無(wú)

其他介紹：國(guó)家級(jí)本科一流課程《組織學(xué)與胚胎學(xué)》主講教師,，參與多門課程的教學(xué)工作,，教學(xué)效果好,。主持及參與多項(xiàng)教研教改和質(zhì)量工程項(xiàng)目，參編教材多部,。曾赴新加坡國(guó)立大學(xué)楊潞齡醫(yī)學(xué)院解剖系訪問學(xué)習(xí)。

       

主持或參加科研項(xiàng)目及人才計(jì)劃項(xiàng)目情況（按時(shí)間倒序排序）：

1.云南省基礎(chǔ)研究計(jì)劃項(xiàng)目（昆醫(yī)聯(lián)合專項(xiàng)-面上項(xiàng)目）, 202401AY07001-216, 天麻素通過TLR4/MyD88/NF-κB通路調(diào)控新生鼠缺血缺氧性腦損傷小膠質(zhì)細(xì)胞極化的機(jī)制研究, 2024/05-2027/04, 10萬(wàn)元, 在研, 參加,。

2.云南省基礎(chǔ)研究計(jì)劃項(xiàng)目（昆醫(yī)聯(lián)合專項(xiàng)-面上項(xiàng)目）, 202401AT070067, 經(jīng)納米材料包封的青藤堿脂質(zhì)體經(jīng)JAK/STAT3通路調(diào)控星形膠質(zhì)極化對(duì)SNI模型神經(jīng)病理性疼痛的影響, 2024/03-2027/02, 10萬(wàn)元,，在研, 參加。

3.云南省基礎(chǔ)研究計(jì)劃項(xiàng)目（昆醫(yī)聯(lián)合專項(xiàng)-面上項(xiàng)目）, 202101AY070001-095, 天麻素通過BDNF/TrkB信號(hào)通路對(duì)HIBD后小膠質(zhì)細(xì)胞和星形膠質(zhì)細(xì)胞間交互作用的調(diào)控機(jī)制研究, 2021/09-2024/09, 10萬(wàn)元, 已結(jié)題, 參加,。

4. 國(guó)家自然科學(xué)基金地區(qū)基金項(xiàng)目,，81960223, 燈盞乙素對(duì)腦缺血后小膠質(zhì)細(xì)胞和星形膠質(zhì)細(xì)胞極化的影響及其對(duì)它們交互作用的調(diào)控研究，2020/01-2023/12,，33.7萬(wàn)元,，已結(jié)題，參加,。

5. 國(guó)家自然科學(xué)基金地區(qū)基金項(xiàng)目,，31760297，天麻素對(duì)新生大鼠缺血缺氧后Notch信號(hào)通路及Sirt3的影響及其調(diào)控機(jī)制的研究,，2018/01-2021/12,，37萬(wàn)元，已結(jié)題,，主持,。

6. 云南省應(yīng)用基礎(chǔ)研究計(jì)劃項(xiàng)目（昆醫(yī)聯(lián)合專項(xiàng)），2018FE001（-189）,，天麻素對(duì)缺血缺氧后神經(jīng)膠質(zhì)細(xì)胞Sirt3蛋白的影響及其調(diào)控機(jī)制的探索，2018/08-2021/09,，10萬(wàn)元,，已結(jié)題，主持,。

7. 云南省教育廳基金項(xiàng)目, 2015C015Y,，依達(dá)拉奉對(duì)腦缺血大鼠小膠質(zhì)細(xì)胞Notch信號(hào)通路的調(diào)節(jié)，2015/10-2017/10,，1萬(wàn)元,，已結(jié)題，主持,。

8．國(guó)家自然科學(xué)基金地區(qū)基金項(xiàng)目,，31460274，天麻素治療在新生大鼠腦缺氧后白質(zhì)損傷中的作用及對(duì)血管緊張素系統(tǒng)影響的研究,，2015/01-2018/12,，48萬(wàn)元，已結(jié)題,，參加,。

9．云南省應(yīng)用基礎(chǔ)研究計(jì)劃項(xiàng)目（重點(diǎn)項(xiàng)目）,，2015FA020，依達(dá)拉奉聯(lián)合燈盞乙素經(jīng)Notch/NF-kB信號(hào)通路對(duì)激活的小膠質(zhì)細(xì)胞神經(jīng)炎癥作用的分子機(jī)制研究,，2015/07-2018/06,，50萬(wàn)元，已結(jié)題,，參加,。

10．國(guó)家自然科學(xué)基金地區(qū)基金項(xiàng)目，31260254,，依達(dá)拉奉聯(lián)合燈盞花素對(duì)腦缺血大鼠神經(jīng)元,、膠質(zhì)細(xì)胞及微血管影響的體內(nèi)、體外實(shí)驗(yàn)研究,，2013/01-2016/12,，50萬(wàn)元，已結(jié)題,，參加,。

代表性成果：

期刊論文：

1. Yuan Y, Fang M, Wu CY, Ling EA*. Scutellarin as a Potential Therapeutic Agent for Microglia-Mediated Neuroinflammation in Cerebral Ischemia. Neuromolecular Med. 18(3):264-273, 2016.

2. Fang M#, Yuan Y#, Lu J, Li HE, Zhao M, Ling EA*, Wu CY*. Scutellarin promotes microglia-mediated astrogliosis coupled with improved behavioral function in cerebral ischemia. Neurochem Int. 97:154-171, 2016.

3. Fang M#, Yuan Y#, Rangarajan P, Lu J, Wu Y, Wang H, Wu C*, Ling EA*. Scutellarin regulates microglia-mediated TNC1 astrocytic reaction and astrogliosis in cerebral ischemia in the adult rats. BMC neuroscience, 16(1):84, 2015.

4. Yuan Y#, Rangarajan P#, Kan EM, Wu Y, Wu C*, Ling EA*. Scutellarin regulates the Notch pathway and affects the migration and morphological transformation of activated microglia in experimentally induced cerebral ischemia in rats and in activated BV-2 microglia. J Neuroinflammation, 20;12:11, 2015.

5. Yuan Y, Zha H, Rangarajan P, Ling EA*, Wu C*. Anti-inflammatory effects of Edaravone and Scutellarin in activated microglia in experimentally induced ischemia injury in rats and in BV-2 microglia. BMC Neurosci, 22;15:125, 2014.

6. Zou YY#, Yuan Y#, Kan EM, Lu J, Ling EA*. Combustion smoke-induced inflammation in the olfactory bulb of adult rats. J Neuroinflammation. 10;11:176, 2014.

7. Wu CY, Fang M, Karthikeyan A, Yuan Y*, Ling EA*. Scutellarin attenuates microglia-mediated neuroinflammation and promotes astrogliosis in cerebral ischemia - a therapeutic consideration. Curr Med Chem. 24:1-10, 2017.

8. Liu SJ, Liu XY, Li JH, Guo J, Li F, Gui Y, Li XH, Yang L, Wu CY, Yuan Y*, Li JJ*. Gastrodin attenuates microglia activation through renin-angiotensin system - Sirtuin3 pathway Neurochem Int. 120:49-63, 2018.

9. Yuan Y, Wu CY, Ling EA*. Heterogeneity of Microglia Phenotypes: Developmental, Functional and Some Therapeutic Considerations. Curr Pharm Des.;25(21):2375-2393, 2019. 

10. Chen HL, Jia WJ, Li HE, Han H, Li F, Zhang XLN, Li JJ, Yuan Y*, Wu CY*. Scutellarin Exerts Anti?Inflammatory Effects in Activated Microglia/Brain Macrophage in Cerebral Ischemia and in Activated BV?2 Microglia Through Regulation of MAPKs Signaling Pathway. Neuromolecular Med. 22(2):264-277, 2020.

11. Guo J, Zhang XLN, Bao ZR, Yang XK, Li LS, Zi Y, Li F, Wu CY, Li JJ*, Yuan Y*. Gastrodin Regulates the Notch Signaling Pathway and Sirt3 in Activated Microglia in Cerebral Hypoxic Ischemia Neonatal Rats and in Activated BV 2 Microglia. Neuromolecular Med. 2021,23(3):348-362 (IF: 4.103)

12. Zhang XLN, Yang XK , Wu CY* , Yun Yuan*.Gastrodin exerts protective effects in reactive TNC1 astrocytes via regulation of the Notch signaling pathway.Ann Transl Med. 9(24):1754-1767, 2021.

13. Xie JP#, Yuan Y#, Tan H#, Bai YF, Zheng QY, Mao L, Wu YS, Wang L, Da WH, Ye QY, Zhang ST, Wang J, Yin WY, Bian YJ, Ma WJ, Zhang LC, Zhang RP, Yu HF, Guo Y*. The combination of living Bifidobacterium, Lactobacillus, and Streptococcus improves social ranking and relieves anxiety-like behavior in competitive mice in a social dominance tube test. Brain Behav. 12(1): e2453, 2022.

14. Guo Y*, Li SD, Zhang LC, Xuan Q, He L, Ye QY, Ma JQ, Peng L, Xiong YX, Yang JY, Yu HF, Xie JP*, Shao H* and Yuan Y*. Depression and anxiety of medical students at Kunming Medical University during COVID-19: A cross-sectional survey. Frontiers in Public health. 10: 957597, 2022. 

15. Chen HL, Yang L, Zhang XLN, Jia QY, Duan ZD, Li JJ, Zheng LY, Liu TT, Qi Z, Yuan Y*, Wu CY*. Scutellarin Acts via MAPKs Pathway to Promote M2 Polarization of Microglial Cells. Molecular Neurobiology. 60(8):4304-4323, 2023. 

16. Yang Y, Yang JY, Ma TT, Yang XK, Yuan Y*, Guo Y*. The role and mechanism of TGF-β1 in the antidepressant-like effects of tetrahydrocurcumin. Eur J Pharmacol. 176075, 2023.