趙永芳

學(xué)歷：博士

專家類別：助理研究員

郵箱：[email protected]

通訊地址：云南省昆明市呈貢區(qū)雨花街道春融西路1168號

郵編：650500

簡歷

教育與工作經(jīng)歷

2023年08月-至今，昆明醫(yī)科大學(xué),，生物醫(yī)學(xué)工程研究院，助理研究員

2019年12月-2022年07月,，美國匹茲堡大學(xué),，醫(yī)學(xué)院，訪問學(xué)者

2016年09月-2023年07月,，復(fù)旦大學(xué)，腦科學(xué)研究員,，博士

2012年09月-2016年06月,，南通大學(xué)，生命科學(xué)學(xué)院,，學(xué)士

研究方向

乳腺癌神經(jīng)腫瘤學(xué)

承擔(dān)科研項目

1. 國家重點研發(fā)計劃（No：2017YFC1308403）：遠(yuǎn)隔缺血適應(yīng)對慢性腦缺血損傷的免疫調(diào)控和血液標(biāo)記物研究（所屬項目：遠(yuǎn)隔缺血適應(yīng)對慢性腦缺血損傷的保護(hù)作用及轉(zhuǎn)化研究）,，2017年09月至2021年06月,，￥2,000,000  ，結(jié)題,，參與

2. 國家自然科學(xué)基金面上項目（No：81870971）：IL-13介導(dǎo)M1型小膠質(zhì)細(xì)胞死亡促進(jìn)顱腦外傷后長期功能修復(fù)的作用機制,，2019年01月至2022年12月，￥560,000  ,，結(jié)題,，參與

研究成果

1. Zhang Y*, Li J*, Zhao Y *，Huang Y, Shi Z, Cao H, Wang C, Wang Y, Gong Y, Yanqin Gao. Arresting the Bad Seed: HDAC3 Regulates Proliferation of Different Microglia after Ischemic Stroke. Science advances.(*co-first author,Revised)

2. Zhang Y*, Zhao Y*, Wang Yn, Li J, Huang Y, Lyv F, Wang Yf, Wei P, Fu Y, Gao Y. 2023. Microglial histone deacetylase 2 is dispensable for functional and histological outcomes in a mouse model of traumatic brain injury. J Cereb Blood Flow Metab. (*co-first author) Accept

3. Zhao Y*, Ma C*, Chen C, Li S, Wang Y, Yang T, Stetler RA, Bennett MVL, Dixon CE, Chen J, Shi Y. 2022. STAT1 contributes to microglial/macrophage inflammation and neurological dysfunction in a mouse model of traumatic brain injury.J Neurosci. JN-RM-0682-22. (* co-first author)  

4. Zhao Y*, Mu H*, Huang Y, Li S, Wang Y, Stetler RA, Bennett MVL, Dixon CE, Chen J, Shi Y. 2022. Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury.J Neuroinflammation. 19(1):201. (* co-first author)  

5. Pu H*, Ma C*, Zhao Y*, Wang Y, Zhang W, Miao W, Yu F, Hu X, Shi Y, Leak RK, Hitchens TK, Dixon CE, Bennett MV, Chen J. 2021. Intranasal delivery of interleukin-4 attenuates chronic cognitive deficits via beneficial microglial responses in experimental traumatic brain injury.J Cereb Blood Flow Metab 41: 2870-86(* co-first author) 

6. Han W, Pu H, Li S, Liu Y, Zhao Y, Xu M, Chen C, Wu Y, Yang T, Ye Q, Wang H. 2023. Targeted ablation of signal transducer and activator of transduction 1 alleviates inflammation by microglia/macrophages and promotes long-term recovery after ischemic stroke.Journal of Neuroinflammation. 20(1):178.

7. Liu Y, Li S, Wang R, Pu H, Zhao Y, Ye Q, Shi Y. 2021. Inhibition of TGFβ-activated kinase 1 promotes inflammation-resolving microglial/macrophage responses and recovery after stroke in ovariectomized female mice.Neurobiol Dis 151: 105257  

8. Miao W, Zhao Y, Huang Y, Chen D, Luo C, Su W, Gao Y. 2020. IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury.J Immunol 204: 1486-98  

9. Zhang J, Zhang W, Gao X, Zhao Y, Chen D, Xu N, Pu H, Stetler RA, Gao Y. 2019. Preconditioning with partial caloric restriction confers long-term protection against grey and white matter injury after transient focal ischemia.J Cereb Blood Flow Metab 39: 1394-409  

10. Mu H, Gao X, Li S, Wei P, Zhao Y, Zhang W, Wang Y, Gao Y. 2019. Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury.CNS Neurosci Ther 25: 1018-29

11. Mao L, Yang T, Li X, Lei X, Sun Y, Zhao Y, Zhang W, Gao Y, Sun B, Zhang F. 2019. Protective effects of sulforaphane in experimental vascular cognitive impairment: Contribution of the Nrf2 pathway.J Cereb Blood Flow Metab 39: 352-66