一,、個(gè)人簡(jiǎn)介

嚴(yán)慧,，博士,，研究員,，碩士生導(dǎo)師,。司法鑒定科學(xué)研究院法醫(yī)毒物法化研究室副主任/研究員,，主持和參與國(guó)家和省部級(jí)科研項(xiàng)目10余項(xiàng),，主持和參與制定毒物毒品鑒定技術(shù)國(guó)家標(biāo)準(zhǔn),、行業(yè)標(biāo)準(zhǔn)20余項(xiàng)，在國(guó)內(nèi)外有影響力的專業(yè)期刊上發(fā)表論文80余篇,參與撰寫《法醫(yī)毒物學(xué)手冊(cè)》等多部專著,，被《法醫(yī)學(xué)雜志》《Forensic science research》等多家雜志聘為專家審稿人,、專業(yè)編輯，曾獲司法部司法為民好榜樣稱號(hào),，上海市科技進(jìn)步一等獎(jiǎng),、三等獎(jiǎng)。

二,、主要研究方向

從事法醫(yī)毒物學(xué)教學(xué)培訓(xùn),、科學(xué)研究及司法鑒定工作，主要研究方向：（1）體內(nèi)毒物及代謝物分析,；（2）新型毒品體內(nèi)外代謝研究,；（3）毒物中毒機(jī)制的代謝組學(xué)研究。

三,、近五年主要承擔(dān)的科研項(xiàng)目

（1）國(guó)家重點(diǎn)研發(fā)計(jì)劃子課題,，新精神活性物質(zhì)篩選數(shù)據(jù)庫(kù)構(gòu)建及預(yù)警系統(tǒng)組建研究，2022.10-2025.9,主持

（2）上海市自然科學(xué)基金項(xiàng)目,，新型毒品5-MeO-DiPT的體內(nèi)代謝和作用機(jī)制研究,，2019.7-2022.6，主持

（3）上海市人才發(fā)展基金,，2020.1-2021.12,，主持

四、近五年代表性成果

[1]Jiao-Jiao Ji, Jiaman Lin, Xin Wang, Hang Chen, Qiran Sun, Duoqi Xu, Ping Xiang,Junling Dun, Hui Yan*, Min Shen*.Estimation of the time of zolpidem intake and differentiation between consumption and external contamination using MALDI-MSI for investigations on single hair samples.Journal of Pharmaceutical and Biomedical Analysis.2024,248: 116272.（IF=3.1）

[2]Yiling Tang, Linhao Xu, Junbo Zhao, Ping Xiang, Hui Yan*.Metabolism of dipentylone in zebrafish and human liver microsomes determined by liquid chromatography–high resolution mass spectrometry.Journal of Pharmaceutical and Biomedical Analysis. 2023,236:115710. （IF=3.1）

[3]Mobing Chen, Wei Liu, Ping Xiang, Linhao Xu, Yiling Tang, Ran Kong, Shuo Yang, Hui Yan*,Bin Di.Development of an LC-MS/MS method for the determination of multiple mycotoxins in human Urine.Food Additives & Contaminants: Part A.2023,40(7):917-927. （IF=2.3）

[4]Linhao Xu,Xinze Liu,Zixuan Song,Ping Xiang,Taijun Hang,Hui Yan*.In vitro and in vivo metabolism of 3-Methoxyeticyclidine inhuman liver microsomes, a zebrafish model, and two human urine samples based on liquid chromatography–high-resolution mass spectrometry.Drug Testing and Analysis. 2023;1–8.DOI: 10.1002/dta.3488. （IF=2.6）

[5]Caixia Guo#,Hui Yan#, Wei Liu,Ping Xiang,Bin Di,Min Shen.Liquid chromatography with tandem mass spectrometric method for determination of 425 drugs and poisons in dried blood spots and application to forensic cases.Forensic Toxicology,2023, https://doi.org/10.1007/s11419-023-00659-9. （IF=2.8）

[6]Xinze Liu, Wei Liu, Ping Xiang, Taijun Hang, Yan Shi, Linna Yue, and Hui Yan*. Metabolism of ADB-4en-PINACA in Zebrafish and Rat Liver Microsomes Determined by Liquid Chromatography–High Resolution Mass Spectrometry.Journal of Analytical Chemistry, 2022,77(8):1036–1046.（IF=1.0）

[7] Mobing Chen, Xinze Liu, Shuo Yang, Zhuonan Chen, Bin Di, Wei Liu*, Hui Yan*.HPLC–MS/MS method for the simultaneous determination of aflatoxins in blood: toxicokinetics of aflatoxin B 1 and aflatoxin M 1 in rats. Journal of Analytical Science and Technology.2022,13:27-37.（IF=2.5）

[8]Kai Zhang#, Hui Yan#, Ruina Liu, Ping Xiang, Kaifei Deng, Ji Zhang, Ya Tuo, Zhenyuan Wan*, Ping Huang*. Exploring metabolic alterations associated with death from asphyxia and the differentiation of asphyxia from sudden cardiac death by GC-HRMS-based untargeted metabolomics. Journal of Chromatography B, doi:10.1016/j.jchromb.2021.122638（IF=2.8）

[9]Yue Linna, Xiang Ping, Shen Baohua, Xu Duoqi, Song Fenyun,  Yan Hui*. Metabolism of 4F-MDMB-BICA in zebrafish by liquid chromatography-high resolution mass spectrometry. Drug Testing and Analysis.2021,13:1223-1229.（IF=2.6）

[10]Zhang Kai#, Yan Hui#, Liu Ruina, Xiang Ping, Zhang Ji, Deng Kaifei,Huang Ping*, Wang Zhenyuan*.The Use of Gas Chromatography Coupled with High-Resolution Mass Spectrometry-Based Untargeted Metabolomics to Discover Metabolic Changes and Help in the Determination of Complex Causes of Death: A Preliminary Study.ACS Omega,2021,6(3):2100-2109.（IF=3.7）

五,、聯(lián)系郵箱: [email protected]