一,、個人簡介

曾曉鋒,，博士,，教授,，博導,，博士后合作導師,。昆明醫(yī)科大學法醫(yī)學院黨委委員,、法醫(yī)學院副院長,、云南省和昆明市中青年學術(shù)和技術(shù)帶頭人,。國家衛(wèi)健委重點實驗室核心成員,，云南省博士導師團隊和昆明醫(yī)科科大學科技創(chuàng)新團隊負責人。現(xiàn)擔任國家一流本科課程和云南省首批拓金課程負責人,。主持國家基金項目4項,，省部級項目8項（重點項目3項），第一作者或通訊作者發(fā)表論文86篇,，其中SCI收錄27篇（IF>5的10余篇）,。主編,、副主編或參編教材及著作19部。獲云南省教學成果一等獎1項,，云南省科技進步三等獎1項,，云南省教學創(chuàng)新大賽二等獎1項，云南省 “挑戰(zhàn)杯”大學生課外學術(shù)科技節(jié)一等獎1項（指導教師）,，授權(quán)發(fā)明專利7項,，實用新型專利12項。

二,、主要研究方向

從事法醫(yī)病理學及法醫(yī)毒物學教學,、科研及司法鑒定工作，主要研究方向：（1）毒品依賴的分子和干預(yù)機制,；（2）毒品與艾滋病協(xié)同神經(jīng)系統(tǒng)損害與干預(yù)機制,；（3）野生菌（毒蕈）中毒的分子機制。

三,、近五年主要承擔的科研項目

（1）國家自然科學基金項目,，82360336，大麻二酚通過環(huán)狀RNAcircDennd1b /mi183-5p/KCNJ5軸干預(yù)甲基苯丙胺依賴的機制研究,，2024.1-2027.12，32萬,，在研,，主持。

（2）國家自然科學基金項目,，8216070410,，Nrf2調(diào)控甲基苯丙胺與HIV-1Tat蛋白協(xié)同激活小膠質(zhì)細胞NLRP3炎性小體介導的神經(jīng)炎癥損傷機制，2022.1-2025.12,，34萬,，在研，主持,。

（3）云南省科技廳-昆明醫(yī)科大學基礎(chǔ)研究聯(lián)合專項（重點項目）,，202201AY070001-020，METH與HIV-1Tat蛋白協(xié)同通過PPAR-γ受體調(diào)控NLRP3炎性小體介導神經(jīng)炎癥機制研究,，2022.09-2025.08,，40萬，在研,、主持,。

（4）云南省科技廳應(yīng)用基礎(chǔ)研究重點項目, 202401AS070059，伏隔核KCNJ5神經(jīng)環(huán)路在METH依賴中的調(diào)控機制及大麻二酚的干預(yù)作用研究,，2024.06-2027.05, 50萬元, 在研, 主持,。

四,、近五年代表性成果

[1] Liu Liu#, Chan Wang#, Haowei Wang, Lin Miao, Tong Xie, Yunqing Tian, Xiaodong Li, Yizhen Huang, Xiaofeng Zeng*, Bofeng Zhu*. Identification of the circRNA–miRNA–mRNA network for treating methamphetamin- induced relapse and behavioral sensitization with cannabidiol. CNS Neuroscience Therapeutics, 2024, 30(5):e14737.（IF=5.5）

[2] Lin Miao#, Haowei Wang#, Yi Li#, Jian Huang, Chan Wang, Hanxin Teng, Lisha Xu, Xue Yang, Yunqing Tian, Genmeng Yang*, Juan Li*, Xiaofeng Zeng*. Mechanisms and treatments of methamphetamine and HIV-1 co-induced neurotoxicity: A systematic review. Frontiers in Immunology, 2024,15:1423263. （IF=5.7）

[3] Haowei Wang#, Genmeng Yang#, Xiaoxing Zhang#, Huijie Zhang, Yan Liu, Chan Wang, Lin Miao, Yi Li, Yizhen Huang, Hanxin Teng , Shangwen Wang*, Hao Cheng*, Xiaofeng Zeng*. Cannabidiol protects the liver from α-Amanitin-induced apoptosis and oxidative stress through the regulation of Nrf2. Food and Chemical Toxicology, 2023,182: 114196.（IF=4.3）

[4] Yue Xu#, Shangwen Wang#, Chi-Kwan Leung Hao Chen, Chan Wang, Huijie Zhang, Shuwei Zhang, Yi Tan, Haowei Wang, Lin Miao, Yi Li, Yizhen Huang, Xiaoxing Zhang, Genmeng Yang*, Ruilin Zhang*, Xiaofeng Zeng*. α-amanitin induces autophagy through AMPK-mTOR-ULK1 signaling pathway in hepatocytes. Toxicology Letters, 2023, 383: 89–97.（IF=3.5）

[5]Shucheng Lin#,Hao Cheng#,Genmeng Yang#,Chan Wang#,ChiKwan Leung, Shuwei Zhang, Yi Tan, Huijie Zhang, Haowei Wang, Lin Miao, Yi Li, Yizhen Huang, Juan Li*, Ruilin Zhang*, Xiaofeng Zeng*. NRF2 antagonizes HIV-1 Tat and methamphetamine-induced BV2 cell ferroptosis by regulating SLC7A11. Neurotoxicity Research, 2023, 41(5):398-407.（IF=3.7）

[6] Genmeng Yang#, Juan Li#, Yanxia Peng#, Baoyu Shen, Yuanyuan Li, Liu Liu, ChanWang, Yue Xu, Shucheng Lin, Shuwei Zhang, Yi Tan, Huijie Zhang, Xiaofeng Zeng*, Qi Li*, Gang Lu*. Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models. Journal of Ginseng Research, 2022, 46 (3) : 426-434.（IF=6.060）

[7] Genmeng Yang#，Juan Li#, Chi-Kwan Leung, Baoyu Shen,，Chan Wang, Yue Xu, Shucheng Lin, Shuwei Zhang, Yi Tan, Huijie Zhang, Xiaofeng Zeng*, Shijun Hong*, Lihua Li*.Methamphetamine and HIV-1 Tat proteins synergistically induce  microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway. Neuropharmacology, 2022, 220:109256. （IF=5.273）

[8] Liu Liu, Jianxing Liu, Ming Zhao, Meiming Cai, Fanzhang Lei, Xiaofeng Zeng*, Bofeng Zhu*. A Bibliometrics and Visualization Analysis of Cannabidiol Research From 2004 to 2021. Frontiers in Pharmacology, 2022, 13:969883. （IF= 5.988）

[9] Liu Liu#, Juan Li#, Chan Wang#, Yue Xu#, Chi-Kwan Leung, Genmeng Yang, Shucheng Lin, Shuwei Zhang, Yi Tan, Huijie Zhang, Haowei Wang, Jianxing Liu*, Ming Li*, Xiaofeng Zeng*.Cannabidiol attenuates methamphetamine-induced conditioned place preference in male rats and viability in PC12 cells through the Sigma1R/AKT/ GSK3β/CREB signaling pathway. American Journal of Drug and Alcohol Abuse, 2022, 48(5):548-561.（IF= 3.912）

[10] Jian Huang#, Ruilin Zhang#, Shangwen Wang#, Dongxian Zhang#, Chi-Kwan Leung, Genmeng Yang, Yuanyuan Li, Liu Liu, Yue Xu, Shucheng Lin, Chan Wang, Xiaofeng Zeng*, Juan Li*. Methamphetamine and HIV-Tat protein synergistically induce oxidative stress and blood-brain barrier damage via transient receptor potential melastatin 2 channel. Frontiers in Pharmacology, 2021, 12:619436.（IF=5.998）

五,、聯(lián)系郵箱: [email protected]