一、個(gè)人簡介

洪仕君,，男,，1974年10月出生,，中共黨員，醫(yī)學(xué)博士,，教授,，博士研究生導(dǎo)師,，博士后合作導(dǎo)師?，F(xiàn)任昆明醫(yī)科大學(xué)法醫(yī)學(xué)院黨委副書記,、院長。

為國家衛(wèi)生健康委員會(huì)毒品依賴和戒治重點(diǎn)實(shí)驗(yàn)室副主任,，云南省高等學(xué)校法醫(yī)學(xué)工程研究中心負(fù)責(zé)人,，云南省博士導(dǎo)師團(tuán)隊(duì)負(fù)責(zé)人，云南省一流課程《法醫(yī)臨床學(xué)》課程負(fù)責(zé)人,，云南省中青年學(xué)術(shù)技術(shù)帶頭人,，昆明醫(yī)科大學(xué)科技創(chuàng)新團(tuán)隊(duì)帶頭人。中國藥物濫用防治協(xié)會(huì)常務(wù)理事,，中國法醫(yī)學(xué)會(huì)第六屆理事,，澳大利亞新西蘭法醫(yī)學(xué)會(huì)（ANZFSS）會(huì)員，入選中華醫(yī)學(xué)會(huì),、云南省醫(yī)學(xué)會(huì)醫(yī)療事故技術(shù)鑒定專家?guī)斐蓡T,，云南省司法鑒定協(xié)會(huì)法醫(yī)類專業(yè)委員會(huì)委員,云南省檢驗(yàn)檢測機(jī)構(gòu)資質(zhì)認(rèn)定評(píng)審員。澳大利亞南澳大學(xué)（Uni SA）訪問學(xué)者,。擔(dān)任中國法醫(yī)學(xué)會(huì)法醫(yī)病理學(xué)及法醫(yī)臨床學(xué)專業(yè)委員會(huì)委員,、海峽兩岸醫(yī)藥衛(wèi)生交流會(huì)法醫(yī)學(xué)分會(huì)常務(wù)委員、云南省司法鑒定協(xié)會(huì)副會(huì)長,、昆明市司法鑒定協(xié)會(huì)會(huì)長,、云南省法學(xué)會(huì)理事、云南省神經(jīng)科學(xué)學(xué)會(huì)理事及云南省心理咨詢師協(xié)會(huì)理事等學(xué)術(shù)團(tuán)體職務(wù),。

從事法醫(yī)學(xué)教學(xué),、科研和司法鑒定社會(huì)服務(wù)27年。主持國家自然科學(xué)基金項(xiàng)目3項(xiàng),，主參與3項(xiàng),；主持云南省應(yīng)用基礎(chǔ)面上項(xiàng)目1項(xiàng)、云南省科技廳－昆明醫(yī)科大學(xué)聯(lián)合專項(xiàng)項(xiàng)目3項(xiàng)（重點(diǎn)項(xiàng)目2項(xiàng),，面上項(xiàng)目1項(xiàng)）,，主參與14項(xiàng)。發(fā)表相關(guān)領(lǐng)域?qū)W術(shù)論文100余篇,，SCI收錄20余篇,。參編國家“十三五”規(guī)劃教材《法醫(yī)毒理學(xué)（第五版）》及《法醫(yī)學(xué)（第二版）》、《環(huán)境損害相關(guān)法醫(yī)學(xué)司法鑒定》,、《高級(jí)法醫(yī)學(xué)》等教材,、專著10余部。獲云南省教學(xué)成果獎(jiǎng)一等獎(jiǎng)一項(xiàng)（排名第五）,，云南省科學(xué)技術(shù)進(jìn)步獎(jiǎng)三等獎(jiǎng)1項(xiàng)（排名第二）,。2024年獲評(píng)司法部全國公共法律服務(wù)先進(jìn)個(gè)人,，2016年獲評(píng)云南司法行政系統(tǒng)“十二五”十佳優(yōu)秀司法鑒定工作者。

二,、主要研究方向：

法醫(yī)毒理學(xué),、毒品依賴機(jī)制與干預(yù)、人體損傷機(jī)制與法醫(yī)學(xué)應(yīng)用,。

三,、近五年主要承擔(dān)科研項(xiàng)目：

1.國家自然科學(xué)基金地區(qū)項(xiàng)目,《神經(jīng)營養(yǎng)因子BDNF、GDNF在甲基苯丙胺濫用/依賴中的作用和機(jī)制》, 2023.01- 2026.12,，主持,。

2.國家自然科學(xué)基金地區(qū)項(xiàng)目，《天麻素干預(yù)甲基苯丙胺依賴大鼠細(xì)胞外調(diào)節(jié)蛋白激酶Ras/Raf/MEK/ERK信號(hào)通路表達(dá)變化及其機(jī)制》（2018.1-2021.12）,，主持,。

3.國家自然科學(xué)基金面上項(xiàng)目,《TRPV1對(duì)甲基苯丙胺依賴記憶印跡的調(diào)控機(jī)制及大麻二酚的干預(yù)作用》（2024.01-2027.12），參與（第二）,。

4.云南省科技廳-昆明醫(yī)科大學(xué)聯(lián)合專項(xiàng)重點(diǎn)項(xiàng)目《Nrf2在甲基苯丙胺誘導(dǎo)的神經(jīng)元線粒體動(dòng)力學(xué)改變與自噬中的作用及大麻二酚的干預(yù)研究》（2023.06-2026.05),，主持。

四,、近五年代表性學(xué)術(shù)成果：

1.Lu Liu , Baoyu Shen, Hanyan Yang , He Zhu, Xi Feng, Ruilin Zhang,* Shijun Hong,*Hongfei Gao* . Acylhydrazone-functionalized triphenylamine V-shaped liquid crystals: Synthesis, columnar self-assembly, gel property and application for the detection of Cu2+. Journal of Molecular Liquids, 399 (2024) 124367.

2.Wenjuan Dong#, Jia Wan# , Hao Yu , Baoyu Shen , Genmeng Yang , Qianyun Nie , Yan Tian , Lixiang Qin, Chunhui Song , Bingzheng Chen, Lihua Li,* Shijun Hong.* Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice[J].Toxicology Letters, 384 (2023) 136-148

3. Jiming Xie#, Shijun Hong# , Xiufeng Zhang , Yuwen Li , Runfang Xie* . Inhibition of glycolysis prevents behavioural changes in mice with MK801-induced SCZ model by alleviating lactate accumulation and lactylation[J].Brain Research 1812 (2023) 148409

4. Baoyu Shen; Dongxian Zhang; Xiaofeng Zeng; Lina Guan; Genmeng Yang; Liu Liu; Jian Huang;Yuanyuan Li; Shijun Hong*; Lihua Li* ; Cannabidiol inhibits methamphetamine-induced dopamine release via modulation of the DRD1-MeCP2-BDNF-TrkB signaling pathway, Psychopharmacology, 2022, 239(5):1521-15372.

5.Baoyu Shen; Ruilin Zhang; Genmeng Yang; Yanxia Peng; Qianyun Nie; Hao Yu; Wenjuan Dong;Bingzheng Chen; Chunhui Song; Yan Tian; Lixiang Qin; Junjie Shu; Shijun Hong*; Lihua Li*;Cannabidiol prevents methamphetamine-induced neurotoxicity by modulating dopamine receptor D1-mediated calcium-dependent phosphorylation of methyl-CpG-binding protein 2, Frontiers in Pharmacology, 2022, 13: 972828.

6.Genmeng Yang; Juan Li; Chi-Kwan Leung; Baoyu Shen; Chan Wang; Yue Xu; Shucheng Lin;Shuwei Zhang; Yi Tan; Huijie Zhang; Xiaofeng Zeng*; Shijun Hong*; Lihua Li *; Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway, Neuropharmacology, 2022, 220: 109256

7.Hao Yu; Yanxia Peng; Wenjuan Dong; Baoyu Shen; Genmeng Yang; Qianyun Nie; Yan Tian;Lixiang Qin; Chunhui Song; Bingzheng Chen; Yongna Zhao; Lihua Li*; Shijun Hong* ; Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice, Human Experimental Toxicology, 2023, 42: 1-11

8. Qianyun Nie; Wenjuan Dong; Baoyu Shen; Genmeng Yang; Hao Yu; Ruilin Zhang; Yanxia Peng;Yang Yu; Shijun Hong*; Lihua Li* ; Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats, Annals of Translational Medicine, 2022, 1(18): 985-985

9.Gen-Meng Yang#; Lu Li#; Feng-Lin Xue; Chen-Li Ma; Xiao-Feng Zeng; Yong-Na Zhao; Shi-Jun Hong*; Li-Hua Li*; The Potential Role of PKA/CREB Signaling Pathway Concerned with Gastrodin Administration on Methamphetamine-Induced Conditioned Place Preference Rats and SH-SY5Y Cell Line, Neurotoxicity Research, 2020, 37: 926-935.

10.C-L Ma#; L Li#; G-M Yang; Z-B Zhang; Y-N Zhao; X-F Zeng; D-X Zhang; Y Yu; Z-J Shi; Q-W Yan; L-H Li*; S-J Hong*; Neuroprotective effect of gastrodin in methamphetamine-induced apoptosis through regulating cAMP/PKA/CREB pathway in cortical neuron, Human and Experimental Toxicology, 2020, 39(8): 1118–1129.

11.Runfang Xie#; Shijun Hong#; Yi Ye; Xueyan Wang; Fan Chen; Lin Yang; Youyi Yan; Linchuan Liao*. Ketamine Affects the Expression of ErbB4 in the Hippocampus and Prefrontal Cortex of Rats, Journal of Molecular Neuroscience, 2020, 70:962–967.

五,、聯(lián)系郵箱:[email protected]